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Methylisothiazolinone: second 'epidemic' of isothiazolinone sensitization

Alergia de Contacto a Metais num Período de 20 Anos no Centro de Portugal: Impl...

Introdução: Os metais são causa frequente de dermatite de contacto alérgica. Desde a introdução da Directiva Comunitária do Níquel (1994/27/CE; 2004/96/CE) e, mais recentemente, da Directiva do Cimento (2003/53/CE), nos países nórdicos tem havido uma diminuição da sensibilização aos metais. A aplicabilidade destas medidas e o seu impacto permanece por avaliar em Portugal.Material e Métodos: Foi realizado um est...

DR(E)SS TO ABACAVIR CONFIRMED BY PATCH TESTS

Abacavir hypersensitivity is a potentially fatal systemic adverse reaction that occurs in 2-9% of exposed patients. Symptoms appear during the first 6 weeks of therapy and are similar to DRESS although usually there is no eosinophilia. Studies have confirmed a positive relation with HLA-B*5701, particularly when only cases confirmed by a positive epicutaneous patch test were considered. This HLA allele is now c...

STEVENS-JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROLYSIS – A 10-YEAR STUDY

Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are uncommon mucocutaneous der- matosis with a potentially fatal outcome, mostly secondary to drug administration. The aim of this retrospective study was to evaluate the clinical and evolutive characteristics of the patients with SJS and TEN admitted to the Dermatology Department of Coimbra University Hospital, between June/2000 and June/2010....

SCLEREDEMA ADULTORUM OF BUSCHKE – CASE REPORT

Scleredema adultorum of Buschke (SAB) is a rare connective tissue disease characterized by non-pitting induration of the skin. Histologically there is thickening of the dermis with large collagen fibers separated by deposits of mucopolysaccharids. A 51-year-old male patient, with poorly controlled diabetes mellitus, progressively developed in a 5-year period, a di- ffuse cutaneous infiltration with ill-defined ...

METASTATIC CUTANEOUS PLASMOCYTOMA IN A PATIENT WITH MULTIPLE MYELOMA

Introduction: In multiple myeloma, the cutaneous lesions are rare and usually occur in late stages of MM as a reflection of increased tumour cell burden. Case report: The authors present the case of a 66 year-old woman with IgG lambda multiple myeloma that, after 16 months and apparently under control haematological, developed a tender and firm erythemato-violaceous plaque, on the back of the right thigh. A dia...

DELAYED HYPERSENSITIVITY TO LOW MOLECULAR WEIGHT HEPARIN - WHAT ALTERNATIVE TO ...

A 75 year-old obese patient was submitted to anticoagulant therapy for deep vein thrombosis (DVT) of the lower limb: classic intravenous heparin for 3 days and subcutaneous dalteparin for 10 days. Three days after the end of treatment the patient developed eczema-like plaques at the subcutaneous low-molecular-weight heparin (LMWH) injec- tion sites. Prick, intradermal and patch tests were performed using hepari...

Specific Dermatoses of Pregnancy

During pregnancy immunological, metabolic, hormonal and vascular changes occur, and can cause specific skin diseases. The specificdermatoses of pregnancy have undergone numerous changes in nomenclature and classification, partly due to advances in the knowledge of the pathogenesis of these skin diseases. Currently the following diseases are considered specific dermatoses of pregnancy:pemphigoid gestations, poly...

Specific Dermatoses of Pregnancy

During pregnancy immunological, metabolic, hormonal and vascular changes occur, and can cause specific skin diseases. The specific dermatoses of pregnancy have undergone numerous changes in nomenclature and classification, partly due to advances in the knowledge of the pathogenesis of these skin diseases. Currently the following diseases are considered specific dermatoses of pregnancy: pemphigoid gestations, po...

Patch testing with 2.0% (0.60 mg/cm2) formaldehyde instead of 1.0% (0.30 mg/cm2...

BACKGROUND: The currently used patch test concentration for formaldehyde is 1.0% (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases of contact allergy to formaldehyde. OBJECTIVES: To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and t...