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Insights into the molecular mechanism of protein native-like aggregation upon m...
Oliveira, Luís M. A.; Gomes, Ricardo A.; Yang, Dennis; Família, Carlos; Lages, Ana; Coelho, Ana V.; Murphy, Regina M.; Quintas, Alexandre"Protein glycation induces structural and stability changes that impair protein function, and is associated with several human neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease and Familial Amyloidotic Polyneuropathy. Recently we have shown that methylglyoxal induces and stabilizes the formation of small native-like aggregates in the amyloidogenic protein insulin and the same was prev...
Insulin glycation by methylglyoxal results in native-like aggregation and inhib...
Oliveira, Luis MA; Lages, Ana; Gomes, Ricardo A; Neves, Henrique; Família, Carlos; Coelho, Ana V; Quintas, AlexandreBackground: Insulin is a hormone that regulates blood glucose homeostasis and is a central protein in a medical condition termed insulin injection amyloidosis. It is intimately associated with glycaemia and is vulnerable to glycation by glucose and other highly reactive carbonyls like methylglyoxal, especially in diabetic conditions. Protein glycation is involved in structure and stability changes that impair p...
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