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Chiral separation of non-steroidal anti-inflammatory drugs by preparative and s...
Ribeiro, António E.; Gomes, Pedro Sá; Pais, L.S.; Rodrigues, A.E.The work presents modelling, simulation and experimental results for the chiral separation of non-steroidal anti-inflammatory drugs, particularly, the optimization of mobile phase composition under preparative and simulated moving bed chromatography. The experimental separation of two chiral systems (ketoprofen and flurbiprofen enantiomers) will be presented to show how compounds of the same family can lead to ...
Advances in simulated moving bed chromatographic separations
Gomes, Pedro Sá; Minceva, M.; Pais, L.S.; Rodrigues, A.E.The development of some unconventional Simulated Moving Bed (SMB) strategies, such as the introduction of nonsynchronous inlet/outlet shifts (the Varicol process), variable flux or variable composition in the inlet/outlet streams (PowerFeed and Modicon, respectively), and also the use of multiple feed or distributed feed, have increased the potential of this technique for a wide range of binary separations. For...
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