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Photocrosslinkable Kappa-carrageenan hydrogels for tissue engineering applications
Mihaila, Silvia M.; Gaharwar, Akhilesh K.; Reis, R. L.; Marques, A. P.; Gomes, Manuela E.; Khademhosseini, AliPublished online ; Kappa carrageenan ( κ -CA) is a natural-origin polymer that closely mimics the glycosaminoglycan structure, one of the most important constituents of native tissues extracellular matrix. Previously, it has been shown that κ -CA can crosslink via ionic interactions rendering strong, but brittle hydrogels. In this study, we introduce photocrosslinkable methacrylate moieties on the κ -CA backbo...
Chondrogenic potential of injectable K-carrageenan hydrogel with encapsulated a...
Popa, Elena G.; Caridade, S. G.; Mano, J. F.; Reis, R. L.; Gomes, Manuela E.Due to the limited self-repair capacity of cartilage, regenerative medicine therapies for the treatment of cartilage defects must use a significant amount of cells, preferably applied using a hydrogel system that can promise their delivery and functionality at the specific site. This paper discusses the potential use of k-carrageenan hydrogels for the delivery of stem cells obtained from adipose tissue in the t...
Cryopreservation of cell laden natural origin hydrogels for cartilage regenerat...
Popa, Elena G.; Rodrigues, Márcia T.; Coutinho, Daniela F.; Oliveira, Mariana B.; Mano, J. F.; Reis, R. L.; Gomes, Manuela E.The time span needed for obtaining a functional cartilage substitute using tissue engineering strategies, together with the need for specific patient oriented constructs has stimulated the growing interest for developing “off-the shelf” products. One way to deliver such products is based on long-term storage processes, such as cryopreservation, that will provide the clinical substitute available as needed and c...
Asymmetric PDLLA membranes containing Bioglass® for guided tissue regeneration ...
Leal, Ana Isabel; Caridade, S. G.; Ma, J.; Yu, N.; Gomes, Manuela E.; Reis, R. L.; Jansen, John A.; Walboomers, X. F.; Mano, J. F.Objective. In the treatment of periodontal defects, composite membranes might be applied to protect the injured area and simultaneously stimulate tissue regeneration. This work describes the development and characterization of poly(d,l-lactic acid)/Bioglass® (PDLLA/BG) composite membranes with asymmetric bioactivity. We hypothesized that the presence of BG microparticles could enhance structural and osteoconduc...
An investigation of the potential application of chitosan/aloe-based membranes ...
Silva, S. S.; Popa, Elena G.; Gomes, Manuela E.; Cerqueira, M. T.; Marques, A. P.; Caridade, S. G.; Teixeira, P.; Sousa, Cláudia; Mano, J. F.A significant number of therapeutics derived from natural polymers and plants have been developed to replace or to be used in conjunction with existing dressing products. The use of the therapeutic properties of aloe vera could be very useful in the creation of active wound dressing materials. The present work was undertaken to examine issues concerning structural features, topography, enzymatic degradation beh...
Unleashing the potential of supercritical fluids for polymer processing in tiss...
Duarte, Ana Rita C.; Santo, Vitor E.; Alves, A.; Silva, S. S.; Moreira-Silva, Joana; Silva, Tiago H.; Marques, A. P.; Gomes, Manuela E.; Sousa, R. A.One of the major scientific challenges that tissue engineering and regenerative medicine (TERM) faces to move from benchtop to bedside regards biomaterials development, despite the latest advances in polymer processing technologies. A variety of scaffolds processing techniques have been developed and include solvent casting and particles leaching, compression molding and particle leaching, thermally induced pha...
Understanding the role of growth factors in modulating stem cell tenogenesis
Gonçalves, A. I.; Rodrigues, Márcia T.; Lee, S. J.; Atala, A.; Yoo, James; Reis, R. L.; Gomes, Manuela E.Current treatments for tendon injuries often fail to fully restore joint biomechanics leading to the recurrence of symptoms, and thus resulting in a significant health problem with a relevant social impact worldwide. Cell-based approaches involving the use of stem cells might enable tailoring a successful tendon regeneration outcome. As growth factors (GFs) powerfully regulate the cell biological response, thei...
Silk hydrogels from non-mulberry and mulberry silkworm cocoons processed with i...
Silva, S. S.; Popa, Elena G.; Gomes, Manuela E.; Oliveira, M. B.; Nayak, S.; Bano, S.; Mano, J. F.; Kundu, S. C.; Reis, R. L.Matrices based on silk fibroin from the non-mulberry silkworm Antheraea mylitta and the mulberry silkworm Bombyx mori have demonstrated good applicability in regenerative medicine. However, the cocoons of A. mylitta are underutilized in part due to their lack of solubility in traditional organic solvents. Therefore, the present work investigates the solubilization and processing of degummed fibers obtained from...
Controlled release strategies for bone, cartilage, and osteochondral engineerin...
Santo, Vitor E.; Gomes, Manuela E.; Mano, J. F.; Reis, R. L.The potential of growth factors to stimulate tissue healing through the enhancement of cell proliferation, migration, and differentiation is undeniable. However, critical parameters on the design of adequate carriers, such as uncontrolled spatiotemporal presence of bioactive factors, inadequate release profiles, and supraphysiological dosages of growth factors, have impaired the translation of these systems ont...
Design and characterization of a biodegradable double-layer scaffold aimed at p...
Requicha, J. F.; Viegas, C. A. A.; Hede, Shantesh; Leonor, I. B.; Reis, R. L.; Gomes, Manuela E.The inefficacy of the currently used therapies in achieving the regeneration ad integrum of the periodontium stimulates the search for alternative approaches, such as tissue-engineering strategies. Therefore, the core objective of this study was to develop a biodegradable double-layer scaffold for periodontal tissue engineering. The design philosophy was based on a double-layered construct obtained from a blend...
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