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Vigilância laboratorial das infeções por Neisseria gonorrhoeae em Portugal, 200...

EzrA contributes to the regulation of cell size in Staphylococcus aureus

EzrA is a negative regulator of FtsZ in Bacillus subtilis, involved in the coordination between cell growth and cell division and in the control of the cell elongation-division cycle. We have now studied the role of the Staphylococcus aureus homologue of the B. subtilis EzrA protein and shown that it is not essential for cell viability. EzrA conditional and null mutants have an overall increase of the average c...

Chlamydia trachomatis infection in patients selected for HPV detection

Background: The significance of the association between the human papillomavirus (HPV) and other sexually transmitted infections in the development of cervical, penile or anal neoplasias has been investigated, and the more consistent data have pointed to an association with Chlamydia trachomatis. In Portugal, the lack of information on STI precludes any knowledge on this subject. Objective: To determine CT infe...

Transcriptomic analysis of plasmid and plasmid-related chromosomal ORFs in C. t...

Despite the undergoing chromosomal size-reduction of Chlamydia trachomatis, almost all strains maintain the conserved 7,5kb plasmid. It has been recently considered a virulence factor, as plasmid-bearing strains evidenced a higher ability to successfully colonize epithelial cells and sustain infection than plasmidless strains. However, the biological role of the eight plasmid ORFs remains poorly characterized. ...

Normalization strategies for real-time expression data in Chlamydia trachomatis

Since Chlamydia trachomatis is a genetically non-tractable pathogen, transcriptomics assumes a fundamental role for the better understanding of its biology. However, the suitability of endogenous controls for normalization of transcriptomic data in this bacterium still needs validation. We aimed to assess the stability of 10 genes for their potential use as endogenous controls in qPCR at both normal and stress ...

Molecular features underlying the higher ecological success of C. trachomatis E...

In the light of the >98% genomic similarity among Chlamydia trachomatis serovars, the higher worldwide ecological success of E and F is enigmatic. We intend to provide a quick overview of the molecular data that distinguish these from the remaining strains. Examples are: - E and F possess a similar chromosomal genetic make-up distinct from the remaining genotypes. Some loci linked to this independent co-segrega...

Probe timing optimization for time-reversal underwater communications

Passive Time Reversal (pTR) is one of the variants of time reversal applicable to digital underwater communications. In passive time reversal a probe-signal is transmitted ahead of the data-signal in order to estimate the channel impulse response for later use as a replica signal in a time reversal mirror fashion. In practice the received probe-signal must be captured in a time-window and, after correlation wit...

Adaptive evolution of the Chlamydia trachomatis dominant antigen reveals distin...

Background: Chlamydia trachomatis is one of the most disseminated human pathogens, for which no vaccine is available yet. Understanding the impact of the host pressure on pathogen antigens is crucial, but so far it was only assessed for highly-restricted geographic areas. We aimed to evaluate the evolutionary picture of the chlamydial key antigen (MOMP), which is one of the leading multi-subunit vaccine candida...

Modeling arrival scattering due to surface roughness

Signal scattering due to surface roughness constitutes one of the most important modeling problems in underwater acoustics when dealing with signal processing at large frequencies (i.e. above 1 kHz). Such modeling requires, in particular, realistic predictions of the ocean surface, which is usually perturbed by the propagation of swells and wind driven surface waves. Most of experimental studies had been dealin...

Tungsten mine waste geopolymeric binder : preliminary hydration products invest...

Geopolymeric mine waste mud (GMWM) binders are obtained from dehydroxylated waste powder mixed with minor quantities of calcium hydroxide, activated with NaOH and waterglass solutions. In this work recent investigations of GMWM binders hydration products have been carried out. The hydration products have been investigated by means of X-ray diffraction (XRD) and scanning electron microscopy/energy dispersive spe...