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TLR9 activation dampens the early inflammatory response to paracoccidioides bra...
Menino, João F.; Saraiva, Margarida; Alves, Ana G. Gomes; Silva, Diogo; Sturme, Mark H. J.; Gomes, Jéssica Angélica Rezende; Pedrosa, JorgeBackground: Paracoccidioides brasiliensis causes paracoccidioidomycosis, one of the most prevalent systemic mycosis in Latin America. Thus, understanding the characteristics of the protective immune response to P. brasiliensis is of interest, as it may reveal targets for disease control. The initiation of the immune response relies on the activation of pattern recognition receptors, among which are TLRs. Both T...
P. brasiliensis virulence is affected by SconC, the negative regulator of inorg...
Menino, João F.; Saraiva, Margarida; Gomes, Jéssica Angélica Rezende; Sturme, Mark H. J.; Pedrosa, Jorge; Castro, António G.; Ludovico, PaulaConidia/mycelium-to-yeast transition of Paracoccidioidesbrasiliensis is a critical step for the establishment of paracoccidioidomycosis, a systemic mycosis endemic in Latin America. Thus, knowledge of the factors that mediate this transition is of major importance for the design of intervention strategies. So far, the only known pre-requisites for the accomplishment of the morphological transition are the tempe...
Functionality of the paracoccidioides mating α-pheromone-receptor system
Gomes, Jéssica Angélica Rezende; Alves, Ana G. Gomes; Menino, João F.; Coelho, Marco; Ludovico, Paula; Gonçalves, Paula; Sturme, Mark H. J.Recent evidence suggests that Paracoccidioides species have the potential to undergo sexual reproduction, although no sexual cycle has been identified either in nature or under laboratory conditions. In the present work we detected low expression levels of the heterothallic MAT loci genes MAT1-1 and MAT1-2, the a-pheromone (PBa) gene, and the a- and apheromone receptor (PREB and PREA) genes in yeast and mycelia...
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