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Endothelial differentiation of human stem cells seeded onto electrospun polyhyd...
Zonari, A. A. C.; Novikoff, S.; Electo, N. R. P.; Breyner, N. M.; Gomes, D. A.; Martins, A.; Neves, N. M.; Reis, R. L.; Goes, A. M.Tissue engineering is based on the association of cultured cells with structural matrices and the incorporation of signaling molecules for inducing tissue regeneration. Despite its enormous potential, tissue engineering faces a major challenge concerning the maintenance of cell viability after the implantation of the constructs. The lack of a functional vasculature within the implant compromises the delivery of...
Nuclear calcium signaling: a cell within a cell
Rodrigues,M.A.; Gomes,D.A.; Nathanson,M.H.; Leite,M.F.Calcium (Ca2+) is a versatile second messenger that regulates a wide range of cellular functions. Although it is not established how a single second messenger coordinates diverse effects within a cell, there is increasing evidence that the spatial patterns of Ca2+ signals may determine their specificity. Ca2+ signaling patterns can vary in different regions of the cell and Ca2+ signals in nuclear and cytoplasmi...
Nitrergic modulation of vasopressin, oxytocin and atrial natriuretic peptide se...
Ventura,R.R.; Gomes,D.A.; Reis,W.L.; Elias,L.L.K.; Castro,M.; Valença,M.M.; Carnio,E.C.; Rettori,V.; McCann,S.M.; Antunes-Rodrigues,J.The central nervous system plays an important role in the control of renal sodium excretion. We present here a brief review of physiologic regulation of hydromineral balance and discuss recent results from our laboratory that focus on the participation of nitrergic, vasopressinergic, and oxytocinergic systems in the regulation of water and sodium excretion under different salt intake and hypertonic blood volume...
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