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Complementarity of conventional and molecular methods in the assessment of fung...
Viegas, Carla; Gomes, Anita Q.; Sabino, RaquelThe handling of waste and compost that occurs frequently in composting plants (compost turning, shredding, and screening) has been shown to be responsible for the release of dust and air borne microorganisms and their compounds in the air. Thermophilic fungi, such as A. fumigatus, have been reported and this kind of contamination in composting facilities has been associated with increased respiratory symptoms a...
Non-coding RNAs: multi-tasking molecules in the cell
Gomes, Anita Q.; Nolasco, Sofia; Soares, HelenaIn the last years it has become increasingly clear that the mammalian transcriptome is highly complex and includes a large number of small non-coding RNAs (sncRNAs) and long noncoding RNAs (lncRNAs). Here we review the biogenesis pathways of the three classes of sncRNAs, namely short interfering RNAs (siRNAs), microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs). These ncRNAs have been extensively studied and ...
Epigenetic and transcriptional signatures of stable versus plastic differentiat...
Schmolka, Nina; Serre, Karine; Grosso, Ana R.; Rei, Margarida; Pennington, Daniel J.; Gomes, Anita Q.; Silva-Santos, BrunoTwo distinct subsets of γδ T cells that produce interleukin 17 (IL-17) (CD27(-) γδ T cells) or interferon-γ (IFN-γ) (CD27(+) γδ T cells) develop in the mouse thymus, but the molecular determinants of their functional potential in the periphery remain unknown. Here we conducted a genome-wide characterization of the methylation patterns of histone H3, along with analysis of mRNA encoding transcription factors, to...
Cellular hypomethylation is associated with impaired nitric oxide production by...
Barroso, M.; Rocha, M. S.; Esse, R.; Gonçalves, I. Jr; Gomes, Anita Q.; Teerlink, T.; Jakobs, C.; Blom, H. J.; Loscalzo, J.; Rivera, I.Hyperhomocysteinemia (HHcy) is a risk factor for vascular disease, but the underlying mechanisms remain incompletely defined. Reduced bioavailability of nitric oxide (NO) is a principal manifestation of underlying endothelial dysfunction, which is an initial event in vascular disease. Inhibition of cellular methylation reactions by S-adenosylhomocysteine (AdoHcy), which accumulates during HHcy, has been suggest...
Identification of a panel of ten cell surface protein antigens associated with ...
Gomes, Anita Q.; Correia, Daniel V.; Grosso, Ana R.; Lança, Telma; Ferreira, Cristina; Lacerda, João F.; Barata, João T.; Gomes da Silva, Maria©2010 Ferrata Storti Foundation. This is an open-access paper ; Background Vγ9Vδ2 T lymphocytes are regarded as promising mediators of cancer immunotherapy due to their capacity to eliminate multiple experimental tumors, particularly within those of hematopoietic origin. However, Vγ9Vδ2 T-cell based lymphoma clinical trials have suffered from the lack of biomarkers that can be used as prognostic of therapeuti...
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