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“Alterações nas Queixas Subjetivas de Memória e na Escala de Depressão Geriátri...

Para avaliar o efeito da suplementação de fosfatidilserina nos resultados obtidos na Escala de Queixas de Memória (EQM) e na Escala de Depressão Geriátrica (EDG), um grupo de adultos e idosos saudáveis (n= 915) com idade 65,65 ± 11,10 anos, e com um nível de scolaridade de 7,56 ± 4,56 anos participaram do estudo. Os participantes foram submetidos a Avaliação Breve do Estado Mental ABEM), Escala de Queixas de M...

Compreensão de metáforas por crianças com síndrome de Asperger : um estudo com ...

A investigação vigente constitui um estudo piloto sobre a compreensão metafórica com crianças com Síndrome de Asperger em idade escolar. A realização deste estudo advém da necessidade da procura de soluções que possam contribuir para a delineação do processo de intervenção terapêutico e educacional, visando dotar estas crianças com ferramentas de apoio à sua integração social. Objetivos: O estudo corrente prete...

Electrospun silk-elastin-like fiber mats for tissue engineering applications

Protein-based polymers are present in a wide variety of organisms fulfilling structural and mechanical roles. Advances in protein engineering and recombinant DNA technology allow the design and production of recombinant protein-based polymers (rPBPs) with an absolute control of its composition. Although the application of recombinant proteins as biomaterials is still an emerging technology, the possibilities ar...

Effect of poling state and morphology of piezoelectric poly(vinylidene fluoride...

This work reports on the influence of polarization and morphology of electroactive poly(vinylidene fluoride), PVDF, on the biological response of myoblast cells. Non-poled, ‘‘poled +’’ and “poled-“ -PVDF were prepared in the form of films. Further, random and aligned electrospun -PVDF fiber mats were also prepared. It is demonstrated that negatively charged surfaces improve cell adhesion and proliferation an...

Plano de comunicação: hábitos alimentares dos jovens portugueses

O intuito deste projecto de investigação é o de fazer um plano de comunicação para alterar o comportamento dos jovens face aos hábitos alimentares. O público-alvo desta comunicação são jovens entre os 16 e 21 anos. O problema em estudo neste trabalho são os hábitos alimentares dos jovens portugueses, tendo como objetivo a melhoria por parte dos jovens dos hábitos alimentares. Uma vez que estamos a alterar compo...

The activity of LE10 peptide on biological membranes using molecular dynamics, ...

Cell-penetrating peptides (CPPs) and antimicrobial peptides (AMPs) are generally defined as small cationic peptides with the ability to interact with lipidic membranes, in a process driven by electrostatic and hydrophobic processes. The interaction with CPPs is known to lead to its translocation across the membrane, while with AMPs lead to membrane damage. Here we present one synthetic anionic peptide, LE10 (L...

Chitosan–lignosulfonates sono-chemically prepared nanoparticles : characterisat...

Due to their recognised properties of biocompatibility, biodegradability and sustainability, chitosan nanocarriers have been successfully used as new delivery systems. In this work, nanoparticles combining chitosan and lignosulfonates were developed for the first time for cosmetic and biomedical applications. The ability of lignosulfonates to act as a counter polyion for stabilisation of chitosan particles, gen...

Keratins and lipids in ethnic hair

Human hair has an important and undeniable relevance in society due to its important role in visual appearance and social communication. Hair is mainly composed of structural proteins, mainly keratin and keratin associated proteins, and lipids. Herein, we report a comprehensive study of the content and distribution of the lipids among ethnic hair, African, Asian and Caucasian hair. More interestingly, we also r...

A synthetic biology approach for the development of recombinant protein-based p...

The search for advanced materials, especially for those bioinspired, has recently been the focus of great research in many fields of application. Due to recent advances in materials characterization and fabrication technologies, and especially through the use of synthetic biology approaches, it is now possible to reengineer novel functionalities and structures of protein-based materials, taking advantage ...

Antibacterial and antifungal activity of a new solvent-cast film based on a fun...