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Functional modifications associated with gastrointestinal tract organogenesis d...

Gomes, Ana S.; Kamisaka, Y.; Harboe, Torstein; Power, Deborah; Rønnestad, I.

Background: Flatfish metamorphosis is a hormone regulated post-embryonic developmental event that transforms a symmetric larva into an asymmetric juvenile. In altricial-gastric teleost fish, differentiation of the stomach takes place after the onset of first feeding, and during metamorphosis dramatic molecular and morphological modifications of the gastrointestinal (GI-) tract occur. Here we present the functio...


Gene structure, transcripts and calciotropic effects of the PTH family of pepti...

Pinheiro, Pedro L. C.; Cardoso, J. C. R.; Gomes, Ana S.; Fuentes, Juan; Power, Deborah; Canario, Adelino V. M.

Background: Parathyroid hormone (PTH) and PTH-related peptide (PTHrP) belong to a family of endocrine factors that share a highly conserved N-terminal region (amino acids 1-34) and play key roles in calcium homeostasis, bone formation and skeletal development. Recently, PTH-like peptide (PTH-L) was identified in teleost fish raising questions about the evolution of these proteins. Although PTH and PTHrP have be...


The serendipitous origin of chordate secretin peptide family members

Cardoso, J. C. R.; Vieira, Florbela A.; Gomes, Ana S.; Power, Deborah

Background: The secretin family is a pleotropic group of brain-gut peptides with affinity for class 2 G-protein coupled receptors (secretin family GPCRs) proposed to have emerged early in the metazoan radiation via gene or genome duplications. In human, 10 members exist and sequence and functional homologues and ligand-receptor pairs have been characterised in representatives of most vertebrate classes. Secreti...


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Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia