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In vitro induction of melanin synthesis and extrusion by tamoxifen
Matamá, Maria Teresa; Araújo, Rita; Preto, Ana; Paulo, Artur Cavaco; Gomes, A. C.Physical appearance has significant importance psychologically and socially, with skin and hair being of prime relevance. Effective ingredients that modulate melanin synthesis are of growing interest. Tamoxifen, a widely used selective oestrogen receptor modulator, SERM, was described occasionally in medical case reports as causing grey hair repigmentation. This work aimed to study, in vitro, the effect of tamo...
Potential of human γD-crystallin for hair damage repair : insights into the mec...
Ribeiro, Artur J.; Matamá, Maria Teresa; Cruz, Célia F.; Gomes, A. C.; Paulo, Artur CavacoThe objective of this work was to develop a new strategy to physically ‘repair’ chemically damaged hair. Hence the human eye γD-crystallin, a protein from the superfamily characterized structurally by the Greek key motif, was studied. The human γD-crystallin was chosen based on the ability of proteins belonging to this superfamily to be involved in the coating of specific structures. Two crystallins were used o...
Functionalization of gauzes with liposomes entrapping an anti-inflammatory drug...
Ferreira, Helena; Matamá, Maria Teresa; Silva, Raquel; Silva, Carla Manuela; Gomes, A. C.; Paulo, Artur CavacoFrom ancientness, suitable materials have been developed to cover the wounds in order to prevent infections and promote proper wound healing. In this study, the successful development of functionalized nonwoven gauzes with liposomes entrapping anti-inflammatory piroxicam is reported. Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) that can suppress a persistent inflammatory response, leading to impr...
Sonochemical and hydrodynamic cavitation reactors for laccase/hydrogen peroxide...
Gonçalves, Idalina; Martins, Madalena A.; Loureiro, A.; Gomes, A. C.; Paulo, Artur Cavaco; Silva, Carla ManuelaArticle in press ; The main goal of this work is to develop a novel and environmental-friendly technology for cotton bleaching with reduced processing costs. This work exploits a combined laccase–hydrogen peroxide process assisted by ultrasound. For this purpose, specific reactors were studied, namely ultrasonic power generator type K8 (850 kHz) and ultrasonic bath equipment Ultrasonic cleaner USC600TH (45 kHz...
Keratin-based peptide : biological evaluation and strengthening properties on r...
Fernandes, Margarida M.; Lima, Cristóvão F.; Loureiro, A.; Gomes, A. C.; Paulo, Artur CavacoA peptide based on a fragment of hair keratin type II cuticular protein, keratin peptide (KP), was studied as a possible strengthening agent for weakened relaxed hair. The peptide was prepared both in aqueous water formulation (WF) and organic solvent formulations (OF), to determine the effect of organic solvents on peptide interaction with hair and the differences in hair recovery. Both peptide formulations we...
Induction of antioxidant defences by diterpenic phenolics in human fibroblasts ...
Carvalho, A. C.; Gomes, A. C.; Wilson, Cristina Pereira; Lima, Cristóvão F.Ageing is characterised by the progressive accumulation of molecular damage, which leads to altered cellular functioning, reduced stress tolerance and susceptibility to diseases. Consumption of fruits, vegetables and herbs has been related with health promotion due to their content in bioactive phytochemicals, which can be used for ageing interventions [1]. In the present work, the ability of the phenolic diter...
Development of dioctadecyldimethylammonium bromide/monoolein liposomes for gene...
Silva, João P. N.; Oliveira, A. C. N.; Gomes, A. C.; Oliveira, M. ElisabeteThe artificial introduction of nucleic acids (NA) into mammalian cells (transfection) has become, in recent years, a well-established procedure in basic and applied research, which allowed the study of gene function and regulation. The advances in this area have made possible the use of these methods for gene-based medicines, which constitute alternative therapeutic approaches. One of the most prominent methods...
Induction of cellular stress responses by phytochemicals for nutritional applic...
Lima, Cristóvão F.; Carvalho, A. C.; Gomes, A. C.; Wilson, Cristina Pereira; Rattan, S. I. S.Aging is an important risk factor for the development of age-related diseases and is associated with decreased cellular antioxidant defenses and impaired stress responses, reducing the ability of cells to cope with stress. As xenobiotics, we hypothesize that, by imposing mild stress on human cells, antioxidant phytochemicals may afford anti-aging properties through induction of stress responses and cellular ant...
Induction of cellular stress responses by phytochemicals for nutritional applic...
Lima, Cristóvão F.; Carvalho, A. C.; Gomes, A. C.; Wilson, Cristina Pereira; Rattan, S. I. S.Aging is an important risk factor for the development of age-related diseases and is associated with decreased cellular antioxidant defenses. Under the scope of the undergoing NaturAge project, our group is currently investigating the ability of some plant extracts and isolated phytochemicals to induce antioxidant defenses through Nrf2/ARE signaling. That, will be associated with possible anti-aging effects usi...
Induction of antioxidant defenses by diterpenic phenolics in human fibroblasts ...
Carvalho, A. C.; Gomes, A. C.; Wilson, Cristina Pereira; Lima, Cristóvão F.Human lifespan is increasing in developed and developing countries, rising considerably the percentage of elderly people. Aging is characterized by the progressive accumulation of molecular damage, which leads to altered cellular functioning, reduced stress tolerance and susceptibility to diseases, such as cancer, neurodegenerative and cardiovascular diseases. Consumption of fruits, vegetables and herbs has bee...
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