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Molecular basis for preferential protective efficacy of antibodies directed to ...
Cerca, Nuno; Jefferson, Kimberly K.; Maira-Litrán, Tomas; Pier, Danielle B.; Kelly-Quintos, Casie; Goldmann, Donald A.; Azeredo, Joana; Pier, Gerald B.Poly-N-acetyl-glucosamine (PNAG) is a staphylococcal surface polysaccharide influencing biofilm formation that is also under investigation for its vaccine potential. Antibodies that bind to PNAG with either low (<15%) or high (>90%) levels of acetate are superior at opsonic and protective activity compared with antibodies that bind to PNAG with only high levels (>70%) of acetate. PNAG is synthesized by four pro...
Protection against Escherichia coli infection by antibody to the Staphylococcus...
Cerca, Nuno; Maira-Litrán, Tomas; Jefferson, Kimberly K.; Grout, Martha; Goldmann, Donald A.; Pier, Gerald B.Poly-N-acetylglucosamine (PNAG) is a surface polysaccharide produced by Staphylococcus aureus and Staphyloccus epidermidis and is an effective target for opsonic and protective Ab for these two organisms. Recently, it has been found that Escherichia coli produces an exo-polysaccharide, designated polyglucosamine, that is biochemically indistinguishable from PNAG. We analyzed 30 E. coli strains isolated from uri...
Immunological similarities between Poly-N-acetyl Glucosamine (PNAG) from Staphy...
Cerca, Nuno; Jefferson, Kimberly K.; Grout, Martha; Goldmann, Donald A.; Azeredo, Joana; Oliveira, Rosário; Pier, Gerald B.
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