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P. brasiliensis virulence is affected by SconC, the negative regulator of inorg...
Menino, João F.; Saraiva, Margarida; Gomes, Jéssica Angélica Rezende; Sturme, Mark H. J.; Pedrosa, Jorge; Castro, António G.; Ludovico, PaulaConidia/mycelium-to-yeast transition of Paracoccidioidesbrasiliensis is a critical step for the establishment of paracoccidioidomycosis, a systemic mycosis endemic in Latin America. Thus, knowledge of the factors that mediate this transition is of major importance for the design of intervention strategies. So far, the only known pre-requisites for the accomplishment of the morphological transition are the tempe...
Molecular biology of the dimorphic fungi Paracoccidioides SPP
Sturme, Mark H. J.; Puccia, Rosana; Goldman, Gustavo H.; Rodrigues, Fernando José dos SantosParacoccidioides spp, herein commonly referred as Paracoccidioides brasiliensis, is the etiological agent of racoccidioidomycosis (PCM), the most prevalent systemic mycosis endemic in Latin America. Many aspects of the biology of P. brasiliensis remain unknown, in particular its ecology and the apparent lack of a sexual reproduction stage in its life cycle. This review will highlight the current knowledge on t...
Chaetoglobosinas produzidas por Chaetomium globosum, fungo endofítico associado...
Momesso,Luciano da S.; Kawano,Cristina Y.; Ribeiro,Patrícia H.; Nomizo,Auro; Goldman,Gustavo H.; Pupo,Mônica T.Endophytes live in association with host plants during all or part of their life cycle without causing any apparent disease. They are considered outstanding and underexploited sources of novel bioactive compounds. Chaetomium globosum was isolated as an endophytic fungus from the healthy leaves of Viguiera robusta. C.globosum is a remarkable producer of chaetoglobosins, which are typically cytotoxic. In this wor...
Trichoderma harzianum transformant has high extracellular alkaline proteinase e...
Goldman,Maria Helena S.; Goldman,Gustavo H.The mycoparasite Trichoderma harzianum produces an alkaline proteinase that may be specifically involved in mycoparasitism. We have constructed transformant strains of this fungus that overexpress this alkaline proteinase. Some of the transformants were assessed for alkaline proteinase activity, and those with higher activity than the wild type were selected for further studies. One of these transformant strain...
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