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Intracellular lithium and cyclic AMP levels are mutually regulated in neuronal ...
Montezinho, L. P.; Duarte, C. B.; Fonseca, C. P.; Glinka, Y.; Layden, B.; Freitas, D. Mota de; Geraldes, C. F. G. C.; Castro, M. M. C. A.In this work, we studied the effect of intracellular 3',5'-cyclic adenosine monophosphate (cAMP) on Li+ transport in SH-SY5Y cells. The cells were stimulated with forskolin, an adenylate cyclase activator, or with the cAMP analogue, dibutyryl-cAMP. It was observed that under forskolin stimulation both the Li+ influx rate constant and the Li+ accumulation in these cells were increased. Dibutyryl-cAMP also increa...
Data: 2004
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Origem: Estudo Geral - Universidade de Coimbra
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