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Diastolic tolerance to systolic pressures closely reflects systolic performance...
Leite-Moreira, AF; Lourenço, AP; Roncon-Albuquerque R, Jr.; Henriques-Coelho, T; Amorim, MJ; Almeida, J; Pinho, P; Gillbert, TCIn animal experiments, elevating systolic pressures induces diastolic dysfunction and may contribute to congestion, a finding not yet translated to humans. Coronary surgery patients (63 ± 8 years) were studied with left ventricular (LV) pressure (n = 17) or pressure-volume (n = 3) catheters, immediately before cardiopulmonary bypass. Single-beat graded pressure elevations were induced by clamping the ascending ...
Time course and mechanisms of left ventricular systolic and diastolic dysfuncti...
Correia-Pinto, J; Tiago Henriques-Coelho; Roncon-Albuquerque R, Jr.; Lourenço, AP; Melo-Rocha, G; Vasques-Nóvoa, F; Gillbert, TCAlthough pulmonary hypertension (PH) selectively overloads the right ventricle (RV), neuroendocrine activation and intrinsic myocardial dysfunction have been described in the left ventricle (LV). In order to establish the timing of LV dysfunction development in PH and to clarify underlying molecular changes, Wistar rats were studied 4 and 6 weeks after subcutaneous injection of monocrotaline (MCT) 60 mg/kg (MCT...
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