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Índice de anisocitose eritrocitária e disfunção endotelial

Introdução: O índice de anisocitose eritrocitária (RDW) foi recentemente apontado como indicador de risco cardiovascular e como possível marcador de disfunção fisiológica global. Um RDW elevado pode reflectir um estado inflamatório e elevado stress oxidativo ambos associados à progressão do processo aterosclerótico. A tonometria arterial periférica (PAT) é um método não invasivo para avaliação da função endotel...

Early vascular alterations in SLE and RA patients--a step towards understanding...

Accelerated atherosclerosis represents a major problem in both systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) patients, and endothelial damage is a key feature of atherogenesis. We aimed to assess early endothelial changes in SLE and RA female patients (127 SLE and 107 RA) without previous CV events. Biomarkers of endothelial cell activation (intercellular adhesion molecule-1 (sICAM-1), vascul...

Forma rara de edema pulmonar agudo:a proposito de um caso clínico

Apresentamos o caso de um homem de 21 anos, que foi submetido a apendicectomia sob anestesia geral e que imediatamente após a extubação desencadeou quadro de edema putmonar agudo. A propósito, faremos uma breve revisão da literatura, enfatizando os mecanismos fisiopatotógicos subjacentes e os aspectos mais importantes do diagnóstico e tratamento.

Cardiologia personalizada: do risco à terapêutica

Body composition phenotypes in systemic lupus erythematosus and rheumatoid arth...

OBJECTIVES: The amount and distribution of fat and lean mass have important implications for health and systemic inflammation may represent a risk for altered body composition. The aim of this study was to analyse whether changes in body composition are similarly associated with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), two inflammatory conditions of different pathogenesis. METHODS: Bod...

Cardiovascular risk profile in systemic lupus erythematosus and rheumatoid arth...

OBJECTIVE: Premature atherosclerosis is well-documented both in Systemic Lupus Erythematosus (SLE) and in Rheumatoid Arthritis (RA) patients, but cardiovascular (CV) risk is particularly high in lupus women. Although conventional CV risk factors do not fully explain the excessive risk in inflammatory diseases, they remain major contributors to atherosclerosis. The aim of the present study was to investigate whe...

Inclusion of Polyphenol Oxidase Substrates in ß-Cyclodextrin: A 1H-NMR Study

A 1H-NMR study of the interactionsbetween ß-cyclodextrin (ß-CD) and included phenolic molecules (chloragenic acid and caffeic acid ) in aqueous medium is reported. The results confirm that inclusion occurs. Data analysis by the continuous variation method shows that all the complexes have 1 : 1 stoichiometries. Values for the apparent association constants of the inclusion compounds are estimated and compared w...

Relativistic particle in a box

The problem of a relativistic spin 1/2 particle confined to a one-dimensional box is solved in a way that resembles closely the solution of the well known quantum-mechanical textbook problem of a non-relativistic particle in a box. The energy levels and probability density are computed and compared with the non-relativistic case

Myocardial perfusion scintigraphy for diagnosis and risk stratification in stab...

In this paper, the indications for myocardial perfusion scintigraphy, the stress methods, the radiopharmacy and the most used methodology are reviewed. The clinical applications of myocardial perfusion scintigraphy, regarding the diagnosis and prognostic stratification in stable angina are emphasised. ; In this paper, the indications for myocardial perfusion scintigraphy, the stress methods, the radiopharmacy ...