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Biodegradable poly(ester amide)s – A remarkable opportunity for the biomedical ...
Fonseca, Ana C.; Gil, Maria H.; Simões, Pedro N.Poly(ester amide)s have emerged in the last years as an important family of biodegradable synthetic polymers. These polymers present both ester and amide linkages in their structure and they gather in the same entity the good degradability of polyesters with the good thermo-mechanical properties of polyamides. Particularly, poly(ester amide)s containing α-amino acids have risen as important materials in the bio...
Electrospun Drug-Eluting Fibers for Biomedical Applications
Natu, Mădălina V.; Sousa, Hermínio C. de; Gil, Maria H.Electrospinning is a simple and versatile method to produce fibers using charged polymer solutions. As drug delivery systems, electrospun fibers are an excellent choice because of easy drug entrapment, high surface area, morphology control and biomimetic characteristics. Various drugs and biomolecules can be easily encapsulated inside or on fiber surface either during electrospinning or through post-processing ...
Ocular injectable formulation assessment for oxidized dextran-based hydrogels
Maia, João; Ribeiro, Maximiano P.; Ventura, Carla; Carvalho, Rui A.; Correia, Ilídio J.; Gil, Maria H.Initiator-free injectable hydrogels are very interesting for drug and/or cell delivery applications, since they can be administered in a minimally invasive way, and avoid the use of potentially harmful chemical initiators. In the current work, oxidized dextran crosslinked with adipic acid dihydrazide hydrogels were further characterized and tuned to produce formulations, with the aim of producing an injectable ...
Solubility of Irgacure® 2959 photoinitiator in supercritical carbon dioxide: Ex...
Coimbra, Patrícia; Fernandes, Daniel; Ferreira, Paula; Gil, Maria H.; Sousa, Hermínio C. deCIBA photoinitiator Irgacure® 2959 is a highly efficient radical photoinitiator for UV curing systems. Furthermore, and due to its proven low cellular toxicity, this photoinitiator can also be employed in the photopolymerization of polymers and copolymers intended for biomedical and tissue engineering applications, not only in conventional pharmaceutically accepted liquid solvents, but also in supercritical CO2...
Supercritical solvent impregnation of ophthalmic drugs on chitosan derivatives
Braga, Mara E. M.; Pato, Maria T. Vaz; Silva, Hélio S. R. Costa; Ferreira, Elisabeth I.; Gil, Maria H.; Duarte, Catarina M. M.; Sousa, Hermínio C. deIn this work, three chitosan derivatives (N-carboxymethyl chitosan (CMC), N-carboxybutyl chitosan (CBC) and N-succinyl chitosan (SCC)) were impregnated with flurbiprofen (an anti-inflammatory drug) and timolol maleate (an anti-glaucoma drug), using a supercritical solvent impregnation (SSI) technique (and employing high pressure CO2 and CO2 + EtOH mixtures) in order to develop hydrogel-type ophthalmic drug deli...
Solubility of Diflunisal in Supercritical Carbon Dioxide
Coimbra, Patrícia; Fernandes, Daniel; Gil, Maria H.; Sousa, Hermínio C. deThe solubility of diflunisal, a nonsteroidal anti-inflammatory drug (NSAID), in supercritical carbon dioxide (scCO2) was measured at (308.2, 318.2, and 328.2) K and in the pressure range from (9.0 up to 25.0) MPa. Results were obtained using a static analytical method. Experimental solubility was found to be between 0.54·10−6 and 8.07·10−6 (in terms of diflunisal mole fraction). Experimental data were satisfact...
Preparation and characterization of flurbiprofen-loaded poly(3-hydroxybutyrate-...
Coimbra, Patrícia A.; Sousa, Hermínio C. de; Gil, Maria H.Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microspheres containing flurbiprofen were prepared by an oil-in-water emulsion solvent evaporation method, in order to develop a particulate drug delivery system for localized administration. A response surface method (RSM) using a central composite design was employed to evaluate the effect of the poly(vinyl alcohol) (PVA) (%, w/v) concentration in the aqueou...
Synthesis of Poly(lauryl acrylate) by Single-Electron Transfer/Degenerative Cha...
Coelho, Jorge F. J.; Carvalho, Erica Y.; Marques, Dina S.; Popov, Anatoliy V.; Goncalves, Pedro M.; Gil, Maria H.Living radical polymerization of lauryl acrylate was achieved by SET/DTLRP in water catalyzed by sodium dithionite. The work describes the synthesis of a highly hydrophobic and polar monomer in aqueous medium. The plots of versus conversion and ln[M]0/[M] versus time are linear, indicating a controlled polymerization. This method leads to alpha,omega-diiodopoly(lauryl acrylate)s that can be further functionali...
Sorption and diffusion of dense carbon dioxide in a biocompatible polymer
Duarte, Ana Rita C.; Martins, Carlos; Coimbra, Patrícia; Gil, Maria H. M.; Sousa, Hermínio C. de; Duarte, Catarina M. M.Mass sorption and diffusion coefficients in one acrylate biocompatible copolymer contacted with supercritical (sc) carbon dioxide are reported. Equilibrium solubility of dense carbon dioxide in poly(methylmethacrylate-co-ethylhexylacrylate-co-ethyleneglycoldimethacrylate) (P(MMA-EHA-EGDMA)) was studied by a gravimetric method in a temperature range from 308 to 323 K and a pressure range from 10.0 to 20.0 MPa. T...
Experimental Determination and Correlation of Artemisinin's Solubility in Super...
Coimbra, Patrícia; Blanco, Miguel R.; Silva, Hélio S. R. Costa; Gil, Maria H.; Sousa, Hermínio C. deThe measurement and correlation of the experimental solubility of the antimalarial artemisinin (Artemisia annua L.) in supercritical carbon dioxide is reported. Results were obtained using a static analytical method at 308.2, 318.2, and 328.2 K, and in a pressure range from 10.0 up to 25.0 MPa. Solubility experimental data were correlated with three density-based models (Chrastil, Bartle, and Méndez-Santiago−Te...
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