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Combined characterisation and biodegradation assessment methodology of mural pa...
Rosado, T; Gil, M; Caldeira, A Teresa; Martins, M Rosario; Dias, C; Carvalho, L; Mirão, J; Candeias, A EThe aim of this work was the material characterisation of wall paintings and biodegradation assessment, including the analysis of microbial growth and the effect of microbial proliferation, in view of their conservation. The methodology was applied to the study of frescoes dated from 1531, located in the ancient parish church of Santo Aleixo, Southern Portugal. The combined use of optical microscopy, SEM-EDS an...
Oxalate biofilm formation in mural paintings due to microorganismse -A comprehe...
Rosado, T; Gil, M; Mirão, J; Candeias, A; Caldeira, A TeresaOxalate film formation is a pathology that often occurs in mural paintings and may result from the concomitant action of microorganisms and environmental conditions. Low Choir of the Convent of Nossa Senhora da Saudação (Portugal) has mural paintings with an extraordinary beauty, which over time have been suffered polychromy degradation and biofilm formation, presenting an ideal case study to investigate the ro...
Designing polymeric microparticles for biomedical and industrial applications
Campos, Elisa; Branquinho, J.; Carreira, Ana S.; Carvalho, Anabela; Coimbra, Patrícia; Ferreira, P.; Gil, M. H.Nowadays, there are almost limitless applications for microparticles. Microparticles are used as components in many advanced materials and composites, in the healthcare and personal grooming industries, and in many research and development applications. This review presents an overview of recent and current studies carried out at the Particles, Polymers and Biomaterials Technology Group of the University of Coi...
Study of Nα-benzoyl-L-argininate ethyl ester chloride, a model compound for pol...
Fonseca, A. C.; Jarmelo, S.; Silva, M. Ramos; Beja, A. M. Matos; Fausto, R.; Gil, M. H.; Simões, P. N.Poly(ester amide)s (PEAs) are lacking in structural and spectroscopic information. This paper reports a structural and spectroscopic characterization of Nα-benzoyl-L-argininate ethyl ester chloride (BAEEH+·Cl−), an important amino acid derivative and an adequate PEAs’ model compound. Crystals of BAEEH+·Cl− obtained by slow evaporation in an ethanol/water mixture were studied by different complementary technique...
In vitro and in vivo evaluation of an intraocular implant for glaucoma treatment
Natu, Mădălina V.; Gaspar, Manuel N.; Ribeiro, Carlos A. Fontes; Cabrita, António M.; Sousa, Hermínio C. de; Gil, M. H.Implantable disks for glaucoma treatment were prepared by blending poly(ɛ-caprolactone), PCL, poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) and dorzolamide. Their in vivo performance was assessed by their capacity to decrease intraocular pressure (IOP) in normotensive and hypertensive eyes. Drug mapping showed that release was complete from blend disks and the low molecular weight (MW) PCL...
Poly(dimethyl siloxane) surface modification with biosurfactants isolated from ...
Pinto, S.; Gonçalves, S.; Gudiña, Eduardo J.; Rodrigues, L. R.; Teixeira, J. A.; Gil, M. H.; Alves, P.; Santos, A. C.Depending on the final application envisaged for a given biomaterial, many surfaces must be modified before use. The material performance in a biological environment is mainly mediated by its surface properties that can be improved using suitable modification methods. The aim of this work was to coat poly(dimethyl siloxane) (PDMS) surfaces with biosurfactants (BSs) and to evaluate how these compounds affect the...
1H NMR Spectroscopic and Quantum Chemical Studies on a Poly(ester amide) Model ...
Fonseca, A. C.; Jarmelo, S.; Carvalho, R. A.; Fausto, R.; Gil, M. H.; Simões, P. N.The molecular structure of the l-arginine derivative, Nα-benzoyl-l-argininate ethyl ester chloride (BAEEH+·Cl−), was characterized by combining quantum chemical methods and 1H NMR spectroscopy. A conformational search on the potential energy surfaces of the three lowest-energy tautomers of BAEEH+ [A: R−N+H═(NH2)2; B: R−NH−C(═NH)N+H3; C: R−N+H2−C(═NH)NH2; R = C6H5C(═O)NH−CH(COOCH2CH3)CH2CH2CH2−] was carried out ...
Role of Guanidyl Moiety in the Insertion of Arginine and Nα-Benzoyl-l-argininat...
Fonseca, A. C.; Frías, M. A.; Bouchet, A. M.; Jarmelo, S.; Simões, P. N.; Fausto, R.; Gil, M. H.; Lairion, F.; Disalvo, E. A.Role of Guanidyl Moiety in the Insertion of Arginine and Nα-Benzoyl-l-argininate Ethyl Ester Chloride in Lipid Membranes AbstractFull Text HTMLHi-Res PDF[1247 KB]PDF w/ Links[216 KB]FiguresReferencesA. C. Fonseca‡, M. A. Frías†, A. M. Bouchet†, S. Jarmelo‡§, P. N. Simões‡, R. Fausto§, M. H. Gil‡, F. Lairion† and E. A. Disalvo*† Laboratory of Physical Chemistry of Lipid Membranes, Department of Analytical Che...
Effects of drug solubility, state and loading on controlled release in bicompon...
Natu, Mădălina V.; Sousa, Hermínio C. de; Gil, M. H.Bicomponent fibers of two semi-crystalline (co)polymers, poly(ɛ-caprolactone), and poly(oxyethylene-b-oxypropylene-b-oxyethylene), were obtained by electrospinning. Acetazolamide and timolol maleate were loaded in the fibers in different concentrations (below and above the drug solubility limit in polymer) in order to determine the effect of drug solubility in polymer, drug state, drug loading and fiber composi...
Poly(dimethyl siloxane) surface modification by low pressure plasma to improve ...
Pinto, S.; Alves, P.; Santos, A. C.; Rodrigues, L. R.; Teixeira, J. A.; Gil, M. H.; Matos, C. B.Poly(dimethyl siloxane) elastomer, (PDMS) is widely used as a biomaterial. However, PDMS is very hydrophobic and easily colonized by several bacteria and yeasts. Consequently, surface modification has been used to improve its wettability and reduce bacterial adhesion. The aim of this work was to modify the PDMS surface in order to improve its hydrophilicity and bacterial cell repulsion to be used as a biomater...
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