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The R6 lines of transgenic mice: A model for screening new therapies for Huntin...
Gil, Joana M.; Rego, A. Cristinahttp://www.sciencedirect.com/science/article/B6SYS-4V59VTB-1/2/2a1ab641b7c1e5d4b9ca6f8c2134bdc0
Mechanisms of neurodegeneration in Huntington's disease
Gil, Joana M.; Rego, Ana CristinaHuntington's disease (HD) is caused by an expansion of cytosine2013adenine2013guanine (CAG) repeats in the huntingtin gene, which leads to neuronal loss in the striatum and cortex and to the appearance of neuronal intranuclear inclusions of mutant huntingtin. Huntingtin plays a role in protein trafficking, vesicle transport, postsynaptic signaling, transcriptional regulation, and apoptosis. Thus, a loss of func...
Reduced hippocampal neurogenesis in R6/2 transgenic Huntington's disease mice
Gil, Joana M. A. C.; Mohapel, Paul; Araújo, Inês M.; Popovic, Natalija; Li, Jia-Yi; Brundin, Patrik; Petersén, ÅsaWe investigated whether cell proliferation and neurogenesis are altered in R6/2 transgenic Huntington's disease mice. Using bromodeoxyuridine (BrdU), we found a progressive decrease in the number of proliferating cells in the dentate gyrus of R6/2 mice. This reduction was detected in pre-symptomatic mice, and by 11.5 weeks, R6/2 mice had 66% fewer newly born cells in the hippocampus. The results were confirmed ...
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