Encontrados 4 documentos, a visualizar página 1 de 1
Lipocalin 2 is present in the EAE brain and is modulated by natalizumab
Marques, Fernanda; Mesquita, Sandro; Sousa, João; Coppola, Giovanni; Gao, Fuying; Geschwind, Daniel H.; Columba-Cabezas, Sandra; Aloisi, FrancescaThe authors acknowledge the BiogenIdec,for providing Natalizumab (BiogenIdec, Boston,MA,USA).We are thankful to theCOST(EuropeanCooperationinScienceandTechnology) ActionNEURINFNETBM0603.WealsothankDr.NadineSantos for criticallyreviewingthismanuscript. ; Multiple sclerosis (MS) is a demyelinating disease that causes major neurological disability in young adults. A definitive diagnosis at the time of the first e...
Transcriptome signature of the adult mouse choroid plexus
Marques, Fernanda Cristina Gomes de Sousa; Sousa, João Carlos; Coppola, Giovanni; Gao, Fuying; Puga, Renato; Brentani, Helena; Geschwind, Daniel H.Background: Although the gene expression profile of several tissues in humans and in rodent animal models has been explored, analysis of the complete choroid plexus (CP) transcriptome is still lacking. A better characterization of the CP transcriptome can provide key insights into its functions as one of the barriers that separate the brain from the periphery and in the production of cerebrospinal fluid. Method...
Altered iron metabolism is part of the choroid plexus response to peripheral in...
Marques, Fernanda; Palha, Joana Almeida; Sousa, Jo??o Carlos; Neves, Margarida Correia; Sousa, Nuno; Falc??o, Ana M.; Coppola, GiovanniIron is essential for normal cellular homeostasis but in excess promotes free radical formation and is detrimental. Therefore, iron metabolism is tightly regulated. Here, we show that mechanisms regulating systemic iron metabolism may also control iron release into the brain at the blood-choroid plexus-cerebrospinal fluid (CSF) barrier. Intraperitoneal administration of lipopolysaccharide (LPS) in mice triggers...
The choroid plexus response to a repeated peripheral inflammatory stimulus
Marques, Fernanda; Sousa, João Carlos; Coppola, Giovanni; Geschwind, Daniel H.; Sousa, Nuno; Palha, Joana Almeida; Neves, Margarida CorreiaBACKGROUND: Chronic systemic inflammation triggers alterations in the central nervous system that may relate to the underlying inflammatory component reported in neurodegenerative disorders such as multiple sclerosis and Alzheimer's disease. However, it is far from being understood whether and how peripheral inflammation contributes to induce brain inflammatory response in such illnesses. As part of the barrier...
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