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Electrochemical measurement of endogenously produced nitric oxide in brain slic...
Ferreira, Nuno R.; Ledo, Ana; Frade, João G.; Gerhardt, Greg A.; Laranjinha, João; Barbosa, Rui M.The role of nitric oxide (NO) as a regulatory diffusible molecule in the brain requires the evaluation of its concentration dynamics. In this work, we have developed microelectrodes suitable for real time electrochemical measurements of NO in vitro. Nafion and o-phenylenediamine were used to modify the surface of carbon fiber microelectrodes (8 [mu]m diameter; [approximate]100 [mu]m tip length). Coating with Na...
Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by ...
Ledo, Ana; Barbosa, Rui M.; Gerhardt, Greg A.; Cadenas, Enrique; Laranjinha, JoãoNitric oxide (*NO) production in response to stimulation of the NMDA glutamate receptor is implicated not only in the synaptic plasticity in hippocampus but may also participate in excitotoxic cell death. Using *NO-selective microssensors inserted into the diffusional field of *NO in acute hippocampal slices, we describe the *NO concentration dynamics evoked by NMDA receptor activation and report profound diffe...
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