Familial amyloid polyneuropathy (FAP) is characterized by deposition of mutated transthyretin (TTR) in the peripheral nervous system. Prior to amyloid fibrils, nonfibrillar TTR aggregates are deposited inducing oxidative stress with increased nitration (3-NT). As the major source of TTR is the liver, liver transplantation (LT) is used to halt FAP. Given the shortage of liver donors, domino LT (DLT) using FAP li...
http://www.sciencedirect.com/science/article/B6VJ0-3XFKHGV-3V/1/21ca47d4f3a98743181f2d76010e13c3
Financiadores do RCAAP | |||||||
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