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Nutraceuticals: a new therapeutic approach against
Santos, António Mário; Oleastro, Mónica; Vale de Gato, Inês; Lopes, Teresa; Seixas, Elsa; Machado, Jorge; Guerreiro, António SousaBackground and Aim: H. pylori induces severe gastric chronic inflammation and is the cause of gastritis, peptic ulcer and a major risk factor for gastric cancer. The aim of the study was to investigate the anti-inflammatory effect of two nutraceuticals in Hp-infected mucosa. Materials and Methods: Eighteen C57BL/6 mice were inoculated with Hp SS1 by gavage three times with 3 · 109 viable cells. Mice were then t...
Helicobacter pylori infection: the role of intestinal
Machado, Jorge; Gato, Inês; Lopes, Teresa; Pereira, Teresa; Santos, Mário; Oleastro, Mónica; Chaves, Paula; Guerreiro, AntónioIntestinal microbiota may influence inflammation in the host. The aim of the present study was to explore the role of modulation of intestinal microbiota in the outcome in the Helicobacter pylori (Hp) gastric inflammation. Twenty five C57BL/6 male mice were separated in three groups: Control group (CG) n = 5 Infected group (IG) n = 10 and Synbiotic 2000TM (SG) n = 10. CG received PBS by gavage; IG and SG were i...
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