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In vitro and in vivo evaluation of an intraocular implant for glaucoma treatment
Natu, Mădălina V.; Gaspar, Manuel N.; Ribeiro, Carlos A. Fontes; Cabrita, António M.; Sousa, Hermínio C. de; Gil, M. H.Implantable disks for glaucoma treatment were prepared by blending poly(ɛ-caprolactone), PCL, poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) and dorzolamide. Their in vivo performance was assessed by their capacity to decrease intraocular pressure (IOP) in normotensive and hypertensive eyes. Drug mapping showed that release was complete from blend disks and the low molecular weight (MW) PCL...
Data: 2011
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Origem: Estudo Geral - Universidade de Coimbra
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