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Use of perfusion bioreactors and large animal models for long bone tissue engin...
Gardel, Leandro S.; Serra, L. A.; Reis, R. L.; Gomes, Manuela E.Tissue engineering and regenerative medicine (TERM) strategies for generation of new bone tissue includes the combined use of autologous or heterologous mesenchymal stem cells (MSC) and three-dimensional (3D) scaffold materials serving as structural support for the cells, that develop into tissue-like substitutes under appropriate in vitro culture conditions. This approach is very important due to the limitatio...
Injectable gellan gum hydrogels with autologous cells for the treatment of rabb...
Oliveira, João T.; Gardel, Leandro. S.; Rada, Tommaso; Martins, L.; Gomes, Manuela E.; Reis, R. L.In this work, the ability of gellan gum hydrogels coupled with autologous cells to regenerate rabbit full-thickness articular cartilage defects was tested. Five study groups were defined: (a) gellangumwith encapsulated chondrogenic predifferentiated rabbit adipose stem cells (ASCþGF); (b) gellan gum with encapsulated nonchondrogenic predifferentiated rabbit adipose stem cells (ASC); (c) gellan gum with encapsul...
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