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Differentiation of mesenchymal stem cells in chitosan scaffolds with double mic...
Garcia Cruz, Dunia M.; Gomes, Manuela E.; Reis, R. L.; Moratal, David; Salmerón-Sánchez, M.; Gómez Ribelles, J. L.; Mano, J. F.Bone Marrow mesenchymal stem cells can be induced to differentiate into osteoblasts to regenerate damaged bone tissue using tissue engineering techniques. In this study, we examine the use of chitosan scaffolds with double pore structure prepared by an innovative method that combines freeze gelation (that produces micropores) and particle leaching out technique (that produces interconnected spherical macropores...
Chitosan microparticles as injectable scaffolds for tissue engineering
Garcia Cruz, Dunia M.; Escobar Ivirico, J. L.; Gomes, Manuela M.; Gómez Ribelles, J. L.; Salmerón-Sánchez, M.; Reis, R. L.; Mano, J. F.The use of chitosan microparticles as injectable carriers for cell transplantation represents a promising alternative to avoid the drawbacks of the implantation of other forms of three-dimensional (3D) scaffolds seeded with cells. In this study, a 3D construct is obtained in vitro by combining chitosan microparticles crosslinked with genipin and goat bone marrow stromal cells (GBMCs). Cell viability and the mor...
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