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Lipocalin 2 is present in the EAE brain and is modulated by natalizumab
Marques, Fernanda; Mesquita, Sandro; Sousa, João; Coppola, Giovanni; Gao, Fuying; Geschwind, Daniel H.; Columba-Cabezas, Sandra; Aloisi, FrancescaThe authors acknowledge the BiogenIdec,for providing Natalizumab (BiogenIdec, Boston,MA,USA).We are thankful to theCOST(EuropeanCooperationinScienceandTechnology) ActionNEURINFNETBM0603.WealsothankDr.NadineSantos for criticallyreviewingthismanuscript. ; Multiple sclerosis (MS) is a demyelinating disease that causes major neurological disability in young adults. A definitive diagnosis at the time of the first e...
Transcriptome signature of the adult mouse choroid plexus
Marques, Fernanda Cristina Gomes de Sousa; Sousa, João Carlos; Coppola, Giovanni; Gao, Fuying; Puga, Renato; Brentani, Helena; Geschwind, Daniel H.Background: Although the gene expression profile of several tissues in humans and in rodent animal models has been explored, analysis of the complete choroid plexus (CP) transcriptome is still lacking. A better characterization of the CP transcriptome can provide key insights into its functions as one of the barriers that separate the brain from the periphery and in the production of cerebrospinal fluid. Method...
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