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Corticosteroid-Induced Immunosuppression ultimately does not compromise the eff...
Martins, Teresa G.; Trigo, Gabriela; Fraga, Alexandra G.; Gama, José B.; Longatto Filho, Adhemar; Saraiva, Margarida; Silva, Manuel T.The authors would like to thank Luis Martins, Deolinda Teixeira and Miguel Carneiro for laboratory assistance. Conceived and designed the experiments: TGM MS MTS AGC JP. Performed the experiments: TGM GT AGF JBG ALF. Analyzed the data: TGM ALF MS MTS AGC JP. Contributed reagents/materials/analysis tools: TGM MS MTS AGC JP. Wrote the paper: TGM AGF ALF MS MTS AGC JP. ; Buruli ulcer (BU) is a necrotizing disease...
Local and regional re-establishment of cellular immunity during curative antibi...
Martins, Teresa G.; Gama, José B.; Fraga, Alexandra G.; Saraiva, Margarida; Silva, Manuel T.; Castro, António G.; Pedrosa, JorgeBACKGROUND: Buruli ulcer (BU) is a neglected necrotizing disease of the skin, subcutaneous tissue and bone, caused by Mycobacterium ulcerans. BU pathogenesis is associated with mycolactone, a lipidic exotoxin with cytotoxic and immunosuppressive properties. Since 2004, the World Health Organization recommends the treatment of BU with a combination of rifampicin and streptomycin (RS). Histological analysis of hu...
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