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The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and eth...
Gago, Bruno; Nyström, Thomas; Cavaleiro, Carlos; Rocha, Bárbara S.; Barbosa, Rui M.; Laranjinha, João; Lundberg, Jon O.By acting as a bioreactor, affording chemical and mechanical conditions for the reaction between dietary components, the stomach may be a source of new bioactive molecules. Using gas chromatography-mass spectrometry we here demonstrate that, under acidic gastric conditions, ethyl nitrite is formed in µM concentrations from the reaction of red wine or distilled alcoholic drinks with physiological amounts of nitr...
LDL Isolated from Plasma-Loaded Red Wine Procyanidins Resist Lipid Oxidation an...
Lourenço, Cátia F.; Gago, Bruno; Barbosa, Rui M.; Freitas, Víctor de; Laranjinha, JoãoDietary phenolic compounds may act as antioxidants in vitro, but because of structural modifications during absorption, its role based on concentrations high enough to afford an antioxidant protection needs to be re-evaluated. We have explored the hypothesis that red wine procyanidins interact with low density lipoproteins (LDL) and that, at this location, the phenolic compounds efficiently protect LDL from oxi...
Red wine-dependent reduction of nitrite to nitric oxide in the stomach
Gago, Bruno; Lundberg, Jon O.; Barbosa, Rui M.; Laranjinha, JoãoNitrite may be a source for nitric oxide (NO), particularly in highly acidic environments, such as the stomach. Diet products contribute also with reductants that dramatically increase the production of NO from nitrite. Red wine has been attributed health promoting properties largely on basis of the reductive antioxidant properties of its polyphenolic fraction. We show in vitro that wine, wine anthocyanin fract...
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