Neste trabalho é apresentada a evolução de um transdutor de pressão para aplicações biomédicas, desenvolvido pelo Laboratório de Biometrologia da PUC-Rio. O mesmo utiliza-se do fenômeno da Magnetoimpedância Gigante (GMI) como elemento intermediário no processo de transdução, o qual compreende a conversão da grandeza pressão em campo magnético e, posteriormente, deste em tensão. Dentre as possíveis aplicações bi...
BACKGROUND & AIMS: Hereditary diffuse gastric cancer (HDGC) families carry CDH1 heterozygous germline mutations; their tumors acquire complete CDH1 inactivation through "2nd-hit" mechanisms. Most frequently, this occurs via promoter hypermethylation (epigenetic modification), and less frequently via CDH1 mutations and loss of heterozygosity (LOH). We quantified the different 2nd hits in CDH1 occurring in neopla...
2008
Haplotype frequencies were determined for 346 individuals from East Timor and 3 major ethnolinguistic groups were compared, putting in evidence the need for detailed analyses below the level of the major ethnolinguistic groups. Search of Timorese haplotypes matches in international databases returns few hits and almost all with Philippine data. ; http://www.sciencedirect.com/science/article/B7581-4JSBXBX-37/...
http://www.sciencedirect.com/science/article/B6T6W-4FVJC03-2/1/4d12524a22b2805e723ce2af692237f6
Allele frequencies for the fifteen STRs included in the AmpF/STR Identifiler (CSF1PO, D2S1338, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D19S433, D21S11, FGA, TH01, TPO and VWA) were estimated from a sample of 186 unrelated individuals from East Timor. No deviations from Hardy-Weinberg equilibrium were observed (only after applying the Bonferroni correction in the cases of D2S1338, TPO and D5S...
In a genetic study of unrelated donors from Bahia (Brazil), one sample contained a 16 Y-STR haplotype with double peaks at three loci: DYS389 II, DYS437 and DYS439. The son of the subject had the same haplotype as found in the father. This profile was compared with a similar case found in a paternity case investigation in Madrid (Spain) and a match was found for the full 16 Y-STR haplotype. Because these three ...
The first population-genetics study for the world newest independent country, East Timor, is presented. In this preliminary work, part of a major ongoing study on East-Timor genetic diversity, the allele frequencies and some statistical parameters of forensic interest were determined for the 15 loci included in AmpFLSTR Identifiler(TM) genotyping kit. A total of 107 samples, collected from East Timorese of seve...
We have analysed the matrilineal genetic composition of three self-reported ethnic groups from São Tomé e Príncipe (Gulf of Guinea), an African archipelago whose settlement begun in the late fifteenth century. Sequence data from the hypervariable segments I (HVS-I) and II (HVS-II) were obtained for 30 Angolares, 35 Forros and 38 Tongas. The repertory of mtDNA lineages in São Tomé e Príncipe denoted a fully Afri...
Seven Y-chromosome STR loci, DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392 and DYS393 have been analysed in population samples of Angolares, Forros and Tongas, three ethnic groups from the African archipelago of São Tomé e Príncipe (Gulf of Guinea). Complete typings were obtained for 103 chromosomes, which belonged to 79 different haplotypes. The mean heterozygosity per locus in the overall São Tomean sample...
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