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Vanadate oligomers: in vivo effects in hepatic vanadium accumulation and stress...
Gândara, Ricardo M. C.; Soares, S. S.; Martins, H.; Gutiérrez-Merino, Carlos; Aureliano, M.The formation of vanadate oligomeric species is often disregarded in studies on vanadate effects in biological systems, particularly in vivo, even though they may interact with high affinity with many proteins. We report the effects in fish hepatic tissue of an acute intravenous exposure (12, 24 h and 7 days) to two vanadium(V) solutions, metavanadate and decavanadate, containing different vanadate oligomers ad...
Decavanadate effects in biological systems
Aureliano, M.; Gândara, Ricardo M. C.Vanadium biological studies often disregarded the formation of decameric vanadate species known to interact, in vitro, with high-affinity with many proteins such as myosin and sarcoplasmic reticulum calcium pump and also to inhibit these biochemical systems involved in energy transduction. Moreover, very few in vivo animal studies involving vanadium consider the contribution of decavanadate to vanadium biologic...
Interactions of vanadium(V)–citrate complexes with the sarcoplasmic reticulum c...
Aureliano, M.; Tiago, Teresa; Gândara, Ricardo M. C.; Sousa, Andrea; Moderno, A.; Kaliva, M.; Salifoglou, A.; Duarte, Rui O.; Moura, José J. G.Among the biotargets interacting with vanadium is the calcium pump from the sarcoplasmic reticulum (SR). To this end, initial research efforts were launched with two vanadium(V)–citrate complexes, namely (NH4)6[V2O4(C6H4O7)2] Æ 6H2O and (NH4)6[V2O2(O2)2(C6H4O7)2] Æ 4H2O, potentially capable of interacting with the SR calcium pump by combining kinetic studies with 51V NMR spectroscopy. Upon dissolution in the re...
Efeitos in vivo de oligómeros de vanadato em marcadores de stresse oxidativo
Gândara, Ricardo M. C.Relatório de estágio de licenciatura, Bioquímica, Faculdade de Ciências e Tecnologia. Universidade do Algarve, 2003 ; Nowadays it is accepted that disturbances in transition metals homeostasis are related to changes in the oxidative status, depleting antioxidant substances and/or raising prooxidant ones or altering the activities of key enzymes in the antioxidant defence. Vanadium is probably involved in such ...
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