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Rapid vascularization of starchâ poly(caprolactone) in vivo by outgrowth endot...
Ghanaati, Shahram; Fuchs, Sabine; Webber, M. J.; Orth, Carina; Barbeck, Mike; Gomes, Manuela E.; Reis, R. L.; Kirkpatrick, C. JamesThe successful integration of in vitro-generated tissues is dependent on adequate vascularization in vivo. Human outgrowth endothelial cells (OECs) isolated from the mononuclear cell fraction of peripheral blood represent a potent population of circulating endothelial progenitors that could provide a cell source for rapid anastomosis and scaffold vascularization. Our previous work with these cells in co-culture...
Contribution of outgrowth endothelial cells from human peripheral blood on in v...
Fuchs, Sabine; Ghanaati, Shahram; Orth, Carina; Barbeck, Mike; Kolbe, Marlen; Hofmann, Alexander; Eblenkamp, Markus; Gomes, Manuela E.; Reis, R. L.In the present study we assessed the potential of human outgrowth endothelial cells (OEC), a subpopulation within endothelial progenitor cell cultures, to support the vascularization of a complex tissue engineered construct for bone. OEC cultured on starch polycaprolactone fiber meshes (SPCL) in monoculture retained their endothelial functionality and responded to angiogenic stimulation by VEGF (vascular endoth...
Surface-modified 3D starch-based scaffold for improved endothelialization for b...
Santos, M. I.; Pashkuleva, I.; Alves, C. M.; Gomes, Manuela E.; Fuchs, Sabine; Unger, Ronald E.; Reis, R. L.; Kirkpatrick, C. JamesProviding adequate vascularization is one of the main hurdles to the widespread clinical application of bone tissue engineering approaches. Due to their unique role in blood vessel formation, endothelial cells (EC) play a key role in the establishment of successful vascularization strategies. However, currently available polymeric materials do not generally support EC growth without coating with adhesive protei...
Endothelial cell colonization and angiogenic potential of combined nano- and mi...
Santos, Marina I.; Tuzlakoglu, K.; Fuchs, Sabine; Gomes, Manuela E.; Peters, K.; Piskin, Erhan; Reis, R. L.; Kirkpatrick, C. James; Unger, Ronald E.Presently the majority of tissue engineering approaches aimed at regenerating bone relies only on postimplantation vascularization. Strategies that include seeding endothelial cells (ECs) on biomaterials and promoting their adhesion, migration and functionality might be a solution for the formation of vascularized bone. Nano/micro-fiber-combined scaffolds have an innovative structure, inspired by extracellular ...
Response of micro- and macrovascular endothelial cells to starch-based fiber me...
Santos, M. I.; Fuchs, Sabine; Gomes, Manuela E.; Unger, Ronald E.; Reis, R. L.; Kirkpatrick, C. JamesThe establishment of a functional vasculature is as yet an unrealized milestone in bone reconstruction therapy. For this study, fibermesh scaffolds obtained from a blend of starch and poly(caprolactone) (SPCL), that have previously been shown to be an excellent material for the proliferation and differentiation of bone marrow cells and thereby represent great potential as constructs for bone regeneration, were ...
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