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The metabolic profile of mitoxantrone and its relation with mitoxantrone-induce...

Rossato, Luciana Grazziotin; Costa, Vera Marisa; de Pinho, Paula Guedes; Arbo, Marcelo Dutra; de Freitas, Vitor; Vilain, Laure; Bastos, Maria de Lourdes

Mitoxantrone (MTX) is an antitumor agent that causes cardiotoxicity in 18 % patients. The metabolic profile of MTX was assessed after incubation of 100 lM MTX with hepatic S9 fraction isolated from rats. The presence of MTX and its metabolites was also assessed in vivo through the analysis of liver and heart extracts of MTX-treated rats. The cytotoxic effects of MTX and MTX metabolites were evaluated in the H9c...

Data: 2013 | Origem: Estudo Geral - Universidade de Coimbra

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Chemical characterization and antioxidant activities of oligomeric and polymeri...

Spranger, Isabel; Sun, Baoshan; Mateus, Ana M.; Freitas, Vitor; Ricardo-da-Silva, Jorge M.

Two procyanidin fractions, namely oligomers and polymers isolated from grape seed methanolic extract were characterized. Phenolic composition and procyanidin purity of these fractions were determined by normal-phase and reverse-phase HPLC, thioacidolysis-HPLC, ESI-MS analyses, formaldehyde–HCl precipitation and elemental analysis. Antioxidant activities of these fractions and other wellknown antioxidants were m...

Data: 2008 | Origem: Repositório da UTL

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