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NOD2 gene mutations in ulcerative colitis: useless or misunderstood?

PURPOSE: NOD2 mutations have been linked to an increased risk of Crohn's disease and to some of its phenotypes. The association between NOD2 mutations and susceptibility to ulcerative colitis (UC) remains somewhat controversial and potential correlations between these mutations and UC phenotype have not been studied. AIM: To assess whether NOD2 mutations are a risk factor for UC in Portugal and if there are any...

Automatic calibration of the SHETRAN hydrological modelling system using MSCE

Automatic calibration is preferred because it provides an objective and extensive searching in the feasible parameter space. In this study, the Modified Shuffled Complex Evolution (MSCE) optimization algorithm is applied to automatically calibrate the physically-based spatially-distributed hydrological model SHETRAN in the 705-km2 semi-arid Cobres basin in southern Portugal, with a spatial resolution of 2 km an...

Rare cause of fever in a patient with ulcerative colitis

O Doente Cirrótico na Unidade de Cuidados Intensivos: Avaliação do Prognóstico

INTRODUÇÃO: Os doentes com cirrose hepática admitidos em Unidades de Cuidados Intensivos (UCI) têm um prognóstico particularmente reservado. O prognóstico destes doentes pode ser avaliado com scores gerais (SOFA, APACHE, SAPS) ou com scores específicos de cirrose hepática (MELD, Child-Pugh). OBJECTIVOS: Avaliar o valor prognóstico dos scores gerais (SOFA, APACHE e SAPS) e dos scores específicos de cirrose hepát...

Comparative vibrational spectra of pilosine and epiisopilosine crystals

This paper describes the study of two alkaloids extracted from Pilocarpus Microphyllus (Rutaceae): pilosine and epiisopilosine. These substances have potential application in the treatment of several diseases. In this work FT-Raman and the FT-IR spectra of pilosine and epiisopilosine were investigated at 300 K. Vibrational wavenumber and wave vector have been predicted using density functional theory (B3LYP) ca...

Polarized Raman spectra of L-arginine hydrochloride monohydrated single crystal

Polarized Raman spectra of L-arginine hydrochloride monohydrated single crystal in nine different scattering geometries of the two irreducible representations of factor group C2 were studied at room temperature. The experimental wavenumber values are compared with those obtained from ab-initio calculation and the assignment of the Raman bands to the respective molecular vibrations is also given. Finally, a disc...

CARD15 mutations and colorectal cancer in a South European country

PURPOSE: CARD15 mutations are associated with higher susceptibility to Crohn's disease (CD) and longstanding colonic CD increases the risk of developing colorectal cancer (CRC). The relation between these mutations and sporadic CRC remains controversial. The aim of this study was to assess whether germline and/or somatic CARD15 mutations are risk factors for sporadic CRC in Portugal and whether there are genoty...

CARD15 Mutations and Perianal Fistulating Crohn’s Disease: Correlation and Pred...

BACKGROUND: CARD15 mutations alter bowel immunity and increase susceptibility to Crohn's disease (CD). However, the relation between these mutations and Crohn's perianal fistulas has not been fully clarified. AIMS: To assess whether CARD15 mutations are associated with risk of developing Crohn's perianal fistulas and whether these mutations are predictors of the response of perianal fistulas to antibiotics. M...

Small-bowel capsule endoscopy in patients with suspected Crohn's disease-diagno...

Background. The aim of this work was to assess the value of capsule enteroscopy in the diagnosis of patients with suspected Crohn's Disease (CD). Methods. This was a retrospective study in a single tertiary care centre involving patients undergoing capsule enteroscopy for suspected CD. Patients taking nonsteroidal anti inflammatory drugs during the thirty preceding days or with a follow-up period of less than s...

CARD15 Mutations and Colorectal Cancer in a South European Country