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Sifuvirtide Screens Rigid Membrane Surfaces. Establishment of a Correlation bet...
Franquelim, Henri G.; Loura, Luís M. S.; Santos, Nuno C.; Castanho, Miguel A. R. B.Sifuvirtide, a 36 amino acid negatively charged peptide, is a novel and promising HIV fusion inhibitor, presently in clinical trials. Because of the aromatic amino acid residues of the peptide, its behavior in aqueous solution and the interaction with lipid-membrane model systems (large unilammelar vesicles) were studied by using mainly fluorescence spectroscopy techniques (both steady-state and time-resolved)....
Data: 2008
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Origem: Estudo Geral - Universidade de Coimbra
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