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Histamine induces ATP release from human subcutaneous fibroblasts via pannexin-...
Pinheiro, Ana Rita; Paramos-de-Carvalho, Diogo; Certal, Mariana; Costa, M. Adelina; Costa, Cristina; Magalhães-Cardoso, Maria TeresaChanges in the regulation of connective tissue ATP-mediated mechano-transduction and remodeling may be an important link to the pathogenesis of chronic pain. It has been demonstrated that mast cell-derived histamine plays an important role in painful fibrotic diseases. Here we analyzed the involvement of ATP in the response of human subcutaneous fibroblasts to histamine. Acute histamine application caused a ris...
Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves AT...
Pinheiro, Ana Rita; Paramos-de-Carvalho, Diogo; Certal, Mariana; Costa, Cristina; Magalhães-Cardoso, Maria Teresa; Ferreirinha, FátimaBackground: Chronic musculoskeletal pain involves connective tissue remodeling triggered by inflammatory mediators, such as bradykinin. Fibroblast cells signaling involve changes in intracellular Ca2+ ([Ca2+]i). ATP has been related to connective tissue mechanotransduction, remodeling and chronic inflammatory pain, via P2 purinoceptors activation. Here, we investigated the involvement of ATP in bradykinin-induc...
Ecto-AMP Deaminase Blunts the ATP-Derived Adenosine A2A Receptor Facilitation o...
Magalhães-Cardoso, M. Teresa; Pereira, M. Fátima; Oliveira, Laura; Ribeiro, J. A.; Cunha, Rodrigo A.; Correia-de-Sá, PauloAt synapses, ATP is released and metabolised through ecto-nucleotidases forming adenosine, which modulates neurotransmitter release through inhibitory A1 or facilitatory A2A receptors, according to the amounts of extracellular adenosine. Neuromuscular junctions possess an ecto-AMP deaminase that can dissociate extracellular ATP catabolism from adenosine formation. In this study we have investigated the pattern ...
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