Encontrados 11 documentos, a visualizar página 1 de 2
Assessment of left ventricular diastolic function with cardiovascular MRI: what...
Duarte, R.; Fernadez-Perez, G.; Bettencourt, N.; Sampaio, F.; Miranda, D.; França, M.; Portugal, P.Abstract Diastolic dysfunction is a common entity and the predominant cause of heart failure in 40%-50% of patients. Diagnosis of diastolic dysfunction is clinically relevant and is associated with a poor prognosis. The aim of this essay was to review the pathophysiology and different grades of diastolic dysfunction and to provide an overview on the role of cardiovascular magnetic resonance imaging in the asses...
From Clinical Presentation to the Outcome: the Natural History of PML in a Port...
Nery, F.; França, M.; Almeida, I.; Vasconcelos, c.Background Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system, associated with immunosuppression states. As there are only some non-published documents concerning PML in HIV infected patients in Portugal, we pretend to characterize natural history of PML infection in a population of HIV patients. Methods We retrospectively reviewed, from 1992 to 2009, PML c...
A case of haemophagocytic syndrome presenting with oculogyric crises
Taipa, R.; Moreira, B.; França, M.; Maia, L.Haemophagocytic lymphohistiocytosis (HLH), also called haemophagocytic syndrome (HPS), is a rare disorder resulting in abnormal proliferation of histiocytes in tissues and organs, including the CNS. HLH can present as a primary disease or occur as a secondary reactive disease. Clinical features are high fever, splenomegaly, cytopenia of two or more cell lines, hypertriglyceridaemia and haemophagocytosis. CNS in...
Imaging of pancreas transplantation and its complications
França, M.; Certo, M.; Martins, L.; Varzim, P.; Teixeira, M.; Castro-Henriques, A.; Ribeiro, A.; Alves, F.Abstract Pancreas transplantation is an effective treatment for type 1 diabetes mellitus and is being increasingly performed worldwide. Early recognition of graft-related complications is fundamental for graft survival; thus, radiologists must be aware of the transplantation technique, pancreas-graft imaging and postoperative complications. We present normal pancreas-graft imaging appearances and the imaging fe...
Análise de decisão multicritério na localização de usinas termoelétricas utiliz...
Zambon,Kátia Lívia; Carneiro,Adriano Alber de França M.; Silva,Antônio Nélson Rodrigues da; Negri,Jean CesariA integração de sistemas de informação geográfica (SIGs) e de métodos de decisão multicritério vêm proporcionando inúmeros benefícios para a resolução de problemas de planejamento e gerenciamento do mundo real. Sob esta ótica, este trabalho se propõe a avaliar as alternativas geradas em ambiente SIG para a localização de usinas termoelétricas (UTEs), aplicando técnicas de análise multicritério no processo de de...
A liver metalloendopeptidase which degrades the circulating hypotensive peptide...
Carvalho,K.M.; Nava,R.A.; França,M.S.F.; Medeiros,M.A.S.; Camarão,G.C.; Juliano,L.A new metalloendopeptidase was purified to apparent homogeneity from a homogenate of normal human liver using successive steps of chromatography on DEAE-cellulose, hydroxyapatite and Sephacryl S-200. The purified enzyme hydrolyzed the Pro7-Phe8 bond of bradykinin and the Ser25-Tyr26 bond of atrial natriuretic peptide. No cleavage was produced in other peptide hormones such as vasopressin, oxytocin or Met- and L...
Partial sequence and toxic effects of granulitoxin, a neurotoxic peptide from t...
Santana,A.N.C.; Leite,A.B.; França,M.S.F.; França,L.; Vale,O.C.; Cunha,R.B.; Ricart,C.A.O.; Sousa,M.V.; Carvalho,K.M.A neurotoxic peptide, granulitoxin (GRX), was isolated from the sea anemone Bunodosoma granulifera. The N-terminal amino acid sequence of GRX is AKTGILDSDGPTVAGNSLSGT and its molecular mass is 4958 Da by electrospray mass spectrometry. This sequence presents a partial degree of homology with other toxins from sea anemones such as Bunodosoma caissarum, Anthopleura fuscoviridis and Anemonia sulcata. However, impo...
Specific fluorogenic substrates for neprilysin (neutral endopeptidase, EC 3.4.2...
Medeiros,M.A.S.; França,M.S.F.; Boileau,G.; Juliano,L.; Carvalho,K.M.Two intramolecularly quenched fluorogenic peptides containing o-aminobenzoyl (Abz) and ethylenediamine 2,4-dinitrophenyl (EDDnp) groups at amino- and carboxyl-terminal amino acid residues, Abz-<!-- $MVD$:face("Times") -->DArg-Arg-Leu-EDDnp (Abz-<!-- $MVD$:face("Times") -->DRRL-EDDnp) and Abz-<!-- $MVD$:face("Times") -->DArg-Arg-Phe-EDDnp (Abz-<!-- $MVD$:face("Times") -->DRRF-EDDnp), were selectively hydrolyzed ...
A new brain metalloendopeptidase which degrades the Alzheimer ß-amyloid 1-40 pe...
Carvalho,K.M.; França,M.S.F.; Camarão,G.C.; Ruchon,A.F.A new metalloendopeptidase was purified to apparent homogeneity from a homogenate of normal human brain using successive steps of chromatography on DEAE-Trisacryl, hydroxylapatite and Sephacryl S-200. The purified enzyme cleaved the Gly33-Leu34 bond of the 25-35 neurotoxic sequence of the Alzheimer ß-amyloid 1-40 peptide producing soluble fragments without neurotoxic effects. This enzyme activity was only inhib...
Antibodies against non-structural c100/3 and structural core antigen of hepatit...
Yoshida,C.F.T.; Takahashi,Y.; Vanderborght,B.O.M.; Rouzere,C.D.; França,M.S.; Takahashi,C.; Takamizawa,A.; Yoshida,I.; Schatzmayr,H.G.Two groups of patients undergoing hemodialysis (HD) maintenance were evaluated for their antibody response to non-structural c100/3 protein and structural core protein of hepatitis C virus (HCV). Forty-six patients (Group 1) never presented liver abnormalities during HD treatment, while 52 patients (Group 2) had either current or prior liver enzyme elevations. Prevalence rates of 32.6% and 41.3% were found for ...
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