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P2Y receptors on astrocytes and microglia mediate opposite effects in astroglia...
Quintas, C; Fraga, S; Gonçalves, J; Queiroz, GloriaNucleotides released upon brain injury signal to astrocytes and microglia playing an important role in astrogliosis, but the participation of microglia in the purinergic modulation of astrogliosis is still unclear. Highly enriched astroglial cultures and co-cultures of astrocytes and microglia were used to investigate the influence of microglia in the modulation of astroglial proliferation mediated by nucleotid...
OPPOSITE MODULATION OF ASTROGLIAL PROLIFERATION BY ADENOSINE 5 -O-(2-THIO)-DIPH...
Quintas, C.; Fraga, S.; Goncalves, J.; Queiroz, G.The contribution of P2Y(12,13) receptors to astroglial proliferation was investigated by testing the effects of two agonists with high affinity for these receptors, adenosine 5-O-(2-thio)-diphosphate (ADP beta S) and 2-methylthioadenosine-5-diphosphate (2-MeSADP), in the incorporation of [(3)H]-thymidine. The effect of ATP, an endogenous inducer of astroglial proliferation, was also investigated. ADP beta S and...
The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release ...
Quintas, C; Fraga, S; Gonçalves, J; Queiroz, GIn the sympathetic nervous system, ATP is a co-transmitter and modulator of transmitter release, inhibiting noradrenaline release by acting on P2Y autoreceptors, but in peripheral tissues the subtypes involved have only scarcely been identified. We investigated the identity of the noradrenaline release-inhibiting P2Y subtypes in the epididymal portion of vas deferens and tail artery of the rat. The subtypes ope...
Fermentação em estado sólido: uma alternativa para o aproveitamento e valorizaç...
PINTO, G. A. S.; BRITO, E. S. de; ANDRADE, A. M. R.; FRAGA, S. L. P.; TEIXEIRA, R. B.2005
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