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Dopaminergic profile of new heterocyclic N-phenylpiperazine derivatives

Web-based application programming interface to solve nonlinear optimization pro...

Nonlinear Optimization Problems are usual in many engineering fields. Due to its characteristics the objective function of some problems might not be differentiable or its derivatives have complex expressions. There are even cases where an analytical expression of the objective function might not be possible to determine either due to its complexity or its cost (monetary, computational, time, ...). In these cas...

High performance liquid chromatography method for quantification of the N-pheny...

A rapid HPLC analytical method was developed and validated for the determination of the N-phenylpiperazine derivative LASSBio-579in plasma rat. Analyses were performed using a C18 column and elution with 20 mM sodium dihydrogen phosphate monohydrate - methanol. The analyte was monitored using a photodiode array detector (257 nm). Calibration curves in spiked plasma were linear over the concentration range of 0....

Atropoisomerismo: o efeito da quiralidade axial em substâncias bioativas

Atropisomerism is a special kind of stereoisomeric relationship that arises from the freezing of a certain conformation of an organic molecule, associated with a high rotational barrier about a single covalent bond. Atropisomerism has been originally described in orto-functionalyzed biphenyl derivatives, but a lot of other organic functionalities can present this structural phenomenon, characterized by the pres...

Re-arquitetura e informação 24 horas no IPA Metodista

A questão da inovação em fármacos no Brasil: proposta de criação do programa na...

Medicines are essential instruments to the preservation, maintenance and promotion of Health. The access to the medicine represents an important factor of social inclusion, depending on the availability of the pharmaceutical - active principle contained in the medicine that in 85% of the cases has a synthetic origin. In this scenario the importance of knowing how to make pharmaceuticals and medicines plays a si...

Vision, kinematics and game strategy in multi-robot systems like MSL RoboCup

In Multi-Robot systems like the RoboCup football challenge, there are a small number of key issues which are of extreme relevance for the successfulness of the final application. In MSL RoboCup these main issues are three: a) The vision system, which has to be as reliable and fast as possible in order to perceive the necessary entities to carry out the game actions; b) Correct kinematics of the robot, that make...

Agentes dopaminérgicos e o tratamento da disfunção erétil

The understanding of the scientific basis of the erectile function expanded rapidly the range of therapies for treating erectile dysfunction in recent years. This article reviews the role of dopamine on the erection mechanisms and its importance for new pro-erectile drug design. The ability of dopaminergic agents to elicit penile erection has been described since 1975 and successively confirmed by numerous stud...

Esquizofrenia: quarenta anos da hipótese dopaminérgica sob a ótica da Química M...

Schizophrenia is a devastating psychiatric illness that affects 1-2% of the world population and continues as a challenge to neuroscience. In this work, we describe an account about the historical evolution of the dopaminergic hypothesis of schizophrenia discussing, from the medicinal chemistry point of view all different classes of antipsychotic drugs, emphasizing the rational design, structure activity relati...

Produtos naturais como candidatos a fármacos úteis no tratamento do Mal de Alzh...

Alzheimer's disease (AD) is a progressive neurodegenerative pathology with severe economic and social impact. There is currently no cure, although cholinesterase inhibitors provide effective temporary relief of symptoms in some patients. Nowadays drug research and development are based on the cholinergic hypothesis that supports the cognition improvement by regulation of the synthesis and release of acetylcholi...