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Phage therapy is effective against infection by Mycobacterium ulcerans in a mur...

Author Summary : Buruli Ulcer (BU), caused by Mycobacterium ulcerans, is a necrotizing disease of the skin, subcutaneous tissue and bone. Standard treatment of BU patients consists of a combination of the antibiotics rifampicin and streptomycin for 8 weeks. However, in advanced stages of the disease, surgical resection of the destroyed skin is still required. The use of bacterial viruses (bacteriophages) for th...

Innovative anti-microbial strategies against buruli ulcer : bacteriophage therapy

Experimental phage therapy against Mycobacterium ulcerans in mice model

Corticosteroid-Induced Immunosuppression ultimately does not compromise the eff...

The authors would like to thank Luis Martins, Deolinda Teixeira and Miguel Carneiro for laboratory assistance. Conceived and designed the experiments: TGM MS MTS AGC JP. Performed the experiments: TGM GT AGF JBG ALF. Analyzed the data: TGM ALF MS MTS AGC JP. Contributed reagents/materials/analysis tools: TGM MS MTS AGC JP. Wrote the paper: TGM AGF ALF MS MTS AGC JP. ; Buruli ulcer (BU) is a necrotizing disease...

Local and regional re-establishment of cellular immunity during curative antibi...

BACKGROUND: Buruli ulcer (BU) is a neglected necrotizing disease of the skin, subcutaneous tissue and bone, caused by Mycobacterium ulcerans. BU pathogenesis is associated with mycolactone, a lipidic exotoxin with cytotoxic and immunosuppressive properties. Since 2004, the World Health Organization recommends the treatment of BU with a combination of rifampicin and streptomycin (RS). Histological analysis of hu...

Cellular immunity confers transient protection in experimental buruli ulcer fol...

The authors would like to thank Luís Martins and Miguel Carneiro for laboratory assistance. Author Contributions Conceived and designed the experiments: AGF AGC JP. Performed the experiments: AGF TGM ET. Analyzed the data: AGF. Contributed reagents/materials/analysis tools: FP. Wrote the paper: AGF KH FP MTS AGC JP. ; BACKGROUND: Buruli ulcer (BU) is an emerging infectious disease caused by Mycobacterium ulcer...

Pathological role of interleukin 17 in mice subjected to repeated BCG vaccinati...

Infection usually leads to the development of acquired immune responses associated with clearance or control of the infecting organism. However, if not adequately regulated, immune-mediated pathology can result. Tuberculosis is a worldwide threat, and development of an effective vaccine requires that the protective immune response to Mycobacterium tuberculosis (Mtb) be dissected from the pathological immune res...

Mycobacterium ulcerans Triggers T-cell immunity followed by local and regional ...

Buruli ulcer (BU) is a neglected infectious disease caused by Mycobacterium ulcerans, characterized by necrotic cutaneous lesions induced by the exotoxin mycolactone. Despite evidence of Th1-mediated protective immunity, M. ulcerans infection has been associated with systemic immunosuppression. We show that early during mouse infection with either mycolactone-positive or negative strains, pathogen-specific IFN-...

Response to treatment in a prospective cohort of patients with large ulcerated ...

BACKGROUND: The World Health Organization (WHO) advises treatment of Mycobacterium ulcerans disease, also called "Buruli ulcer" (BU), with a combination of the antibiotics rifampicin and streptomycin (R+S), whether followed by surgery or not. In endemic areas, a clinical case definition is recommended. We evaluated the effectiveness of this strategy in a series of patients with large ulcers of > or =10 cm in lo...

Fine-needle aspiration, an efficient sampling technique for bacteriological dia...

Invasive punch or incisional skin biopsy specimens are currently employed for the bacteriological confirmation of the clinical diagnosis of Buruli ulcer (BU), a cutaneous infectious disease caused by Mycobacterium ulcerans. The efficacy of fine-needle aspirates (FNA) using fine-gauge needles (23G by 25 mm) for the laboratory confirmation of BU was compared with that of skin tissue fragments obtained in parallel...