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Pathological role of interleukin 17 in mice subjected to repeated BCG vaccinati...
Castro, Ant??nio G.; Fraga, Alexandra G.; Fountain, Jeffrey J.; Rangel-Moreno, Javier; Torrado, Eg??dio; Saraiva, MargaridaInfection usually leads to the development of acquired immune responses associated with clearance or control of the infecting organism. However, if not adequately regulated, immune-mediated pathology can result. Tuberculosis is a worldwide threat, and development of an effective vaccine requires that the protective immune response to Mycobacterium tuberculosis (Mtb) be dissected from the pathological immune res...
Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a nov...
Coelho, Maria Teixeira; Robinson, Richard T.; Khader, Shabaana A.; Martino, Cynthia A.; Fountain, Jeffrey J.; Pearl, John E.; Smiley, Stephen T.RNA splicing is an increasingly recognized regulator of immunity. Here, we demonstrate that after Mycobacterium tuberculosis infection (mRNA) il12rb1 is spliced by dendritic cells (DCs) to form an alternative (mRNA) il12rb1Deltatm that encodes the protein IL-12Rbeta1DeltaTM. Compared with IL-12Rbeta1, IL-12Rbeta1DeltaTM contains an altered C-terminal sequence and lacks a transmembrane domain. Expression of IL-1...
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