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Experimental studies on the mechanisms of tiaprofenic acid photosensitization
Figueiredo, A; Fontes-Ribeiro, CA; Gonçalo, Margarida; Poiares-Baptista, A; Teixeira, FRed blood cell lysis and histidine degradation, photosensitized by tiaprofenic acid (TIA), were investigated. Photohaemolysis was markedly enhanced in oxygenated solutions, but was also intense in the presence of nitrogen. Photohaemolysis was inhibited by butylated hydroxyanisole and reduced glutathione, but was unaffected by sodium azide, superoxide dismutase and mannitol. The TIA-induced photo-oxidation of hi...
Photosensitivity to piroxicam: absence of cross-reaction with tenoxicam
Gonçalo, Margarida; Figueiredo, A; Tavares, P; Fontes-Ribeiro, CA; Teixeira, F; Poiares-Baptista, AWe studied 2 groups of patients. One group of 10 patients had a photosensitive eruption to piroxicam. Another group of 24 patients had positive patch test reactions to thimerosal and thiosalicylic acid and had never taken piroxicam or tenoxicam. Patients were patch tested with thimerosal 0.1% pet., thiosalicylic acid 0.1% pet., salicylic acid 2.0% pet., piroxicam 1 and 5% pet. and tenoxicam 1 and 5% pet. Photop...
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