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Transfusion of RHD negative patients with RHD positive red cells concentrates: ...

Barra, A; Barradas, A; Cardoso, E; Costa, C; Fontes, A; Gil, A; Oliveira, C; Pereira, F; Rebelo, S

Background: In transfusion practice we should respect the ABO group and the Rh phenotype. The lack of availability of red cells concentrates [RCC] RhD negative in the quantities desired, do nol always make it possible to satisfy that requirement, especially in urgency. In our practice we never transfuse RhD in some groups of patients RhD negative, like women of childbearing age, children, newborns, patients wit...

Data: 2011 | Origem: Repositório do Hospital Prof. Doutor Fernando Fonseca

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Prevalence of HLA antibodies in post pregnancies female blood donors

Barra, A; Barradas, A; Cardoso, E; Costa, C; Fontes, A; Gil, A; Oliveira, C; Ramalhete, L; Rodrigues, T; Sancho, MR; Silva, I; Simões, A; Trindade, H

Background: Transfusion related acute lung injury (TRALI) is known as transfusion hazard with high morbidity and mortality rate. Mainly HLA class II have been associated with TRALI. Preventive measures are in the exclusion of donor female as they carry any these antibodies. Aim: We study a group of female blood donor with prior history of two or more pregnancies (G2), one (G1) pregnancy and without any pregn...

Data: 2011 | Origem: Repositório do Hospital Prof. Doutor Fernando Fonseca

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Transfusion therapy and sickle cell disease

Barra, A; Barradas, A; Cardoso, E; Costa, C; Ferreira, R; Fontes, A; Mota, M; Moura, H; Oliveira, C; Pereira, F; Rebelo, S; Rodrigues, T; Santos, L

Background: Sickle cell disease is a very common hemoglobinopathy. The main goal of transfusion therapy in sickle cell disease is to prevent thrombotic events, improve tissue oxygenation and treat anaemia complications. However the risk of all immunization is well known. Since 2001 our service has been doing a tight surveillance work in sickle cell patients, creating a database of about 15,000 studied blood d...

Data: 2011 | Origem: Repositório do Hospital Prof. Doutor Fernando Fonseca

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Mesenchymal stem cells from patients with chronic myeloid leukemia do not expre...

Carrara,R.C.V.; Orellana,M.D.; Fontes,A.M.; Palma,P.V.B.; Kashima,S.; Mendes,M.R.; Coutinho,M.A.; Voltarelli,J.C.; Covas,D.T.

Bone marrow is a heterogeneous cell population which includes hematopoietic and mesenchymal progenitor cells. Dysregulated hematopoiesis occurs in chronic myelogenous leukemia (CML), being caused at least in part by abnormalities in the hematopoietic progenitors. However, the role of mesenchymal stem cells (MSCs) in CML has not been well characterized. The objectives of the present study were to observe the bio...

Data: 2007 | Origem: OASIS br

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Síntese e caracterização de complexos de platina (II) contendo iodeto e derivad...

Guerra,W.; Silva,H.; Almeida,M. V. de; Fontes,A. P. S.

Alguns compostos de platina (II), como por exemplo, cisplatina, carboplatina e oxaloplatina, têm sido utilizados como agentes quimioterápicos no tratamento de vários tipos de câncer. Contudo, na tentativa de reduzir a toxicidade e ampliar o espectro de atividade da cisplatina e de seus análogos, milhares de complexos têm sido preparados variando a natureza dos ligantes. Este trabalho descreve a síntese e caract...

Data: 2006 | Origem: OASIS br

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