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Molecular characterization and T and B cell epitopes prediction of Mycoplasma s...

Mycoplasma sinoviae is a major pathogen of poultry causing synovitis and respiratory infection. M. synoviae hemagglutinin (VlhA) is a lipoprotein encoded by related multigene families that appear to have arisen by horizontal gene transfer. It is an abundant immunodominant surface protein involved in host-parasite interaction mediating binding to host erythrocytes. Herein, we have performed in silico analysis of...

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Aluminum hydroxide associated to Schistosoma mansoni 22.6 kDa protein abrogates...

The need to develop a vaccine against schistosomiasis led several researches and our group to investigate proteins from Schistosoma mansoni as vaccine candidates. Sm22.6 is a protein from S. mansoni that shows high identity with Sj22.6 and Sh22.6 (79 and 91%, respectively). These proteins are associated with high levels of IgE and protection to reinfection. Previously, we have shown that Sm22.6 induced a partia...

Schistosoma mansoni antigen-driven interleukin-10 production in infected asthma...

Asthmatics infected with Schistosoma mansoni have a less severe course of asthma and an inhibition of the Th2 inflammatory response that seems to be mediated by interleukin (IL-10). The objective of this study was to evaluate the capacity of some S. mansoni antigens to stimulate IL-10 production in vitro by cells of asthmatic infected individuals. Peripheral bloods mononuclear cells were stimulated with the S. ...

Náuseas e vômitos no pós-operatório: uma revisão do "pequeno-grande" problema

JUSTIFICATIVA E OBJETIVOS: Apesar da investigação contínua e do desenvolvimento de novos fármacos e técnicas, as náuseas e vômitos no pós-operatório (NVPO) são freqüentes e podem contribuir para o desenvolvimento de complicações com conseqüente aumento dos custos hospitalares e dos recursos humanos. Os objetivos deste artigo são a revisão dos mecanismos fisiológicos, dos fatores de risco e das medidas terapêuti...

Targeting of sterically stabilised pH-sensitive liposomes to human T-leukaemia ...

The main aim of this work was to develop novel targeted sterically stabilised pH-sensitive liposomes tailored to promote efficient intracellular delivery of therapeutic molecules into human T-leukaemia cells. Our results indicate that the targeting moiety (thiolated transferrin) was successfully coupled to the distal reactive maleimide terminus of poly(ethylene glycol)-phospholipid conjugates incorporated in th...

How compensation policy based on EVA performance reduces the conflict between m...

There is a well-known conflict between managers and shareholders, superbly illustrated by the agency theory. A way for shareholders to ensure that managers will perform optimally, by taking the best actions and decisions, is to tie managers’ compensation to the performance of the firms. However, how can we fairly measure their performance? The Economic Value Added (EVA) methodology seems to be a good solution; ...

On the formulation of pH-sensitive liposomes with long circulation times

Strategies used to enhance liposome-mediated drug delivery in vivo include the enhancement of stability and circulation time in the bloodstream, targeting to specific tissues or cells, and facilitation of intracytoplasmic delivery. pH-sensitive liposomes have been developed to mediate the introduction of highly hydrophilic molecules or macromolecules into the cytoplasm. These liposomes destabilize under acidic ...

Política, atores e interesses no processo de mudança institucional: a criação d...

Este trabalho analisa a criação do Ministério da Saúde, em 1953, por meio da identificação dos principais agentes envolvidos, seus interesses e estratégias utilizadas para atingir seus objetivos e influenciar o processo de mudança institucional. Relacionando este processo às características particulares do contexto político da época, identificaremos, entre as arenas de decisão, aquela que ganhou relevância; apr...

Paclitaxel-loaded PLGA nanoparticles: preparation, physicochemical characteriza...

The main objective of this study was to develop a polymeric drug delivery system for paclitaxel, intended to be intravenously administered, capable of improving the therapeutic index of the drug and devoid of the adverse effects of Cremophor® EL. To achieve this goal paclitaxel (Ptx)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (Ptx-PLGA-Nps) were prepared by the interfacial deposition method. The...