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Noninvasive assessment of endothelial function and ST segment changes during ex...
Chequer,G.; Navarro,T.P.; Nascimento,B.R.; Falqueto,E.B.; Nascimento,D.C.; Alencar,M.C.N.; Mandil,A.; Saad,J.A.; Fonseca,C.P.; Ribeiro,A.L.Endothelial function (EF) plays an important role in the onset and clinical course of atherosclerosis, although its relationship with the presence and extent of coronary artery disease (CAD) has not been well defined. We evaluated EF and the ST segment response to an exercise test in patients with a broad spectrum of CAD defined by coronary angiography. Sixty-two patients submitted to diagnostic catheterization...
Estrogen protection in Parkinson´s disease – a GDNF role?
Batista, C.; Fonseca, C. P.; Campos, F.; Cristóvão, A.; Almeida, L. P. de; Baltazar, G.Estrogen protection in Parkinson´s disease – a GDNF role?
Effects of Li+ transport and intracellular binding on Li+/Mg2+ competition in b...
Fonseca, C. P.; Montezinho, L. P.; Nabais, C.; Tomé, A. R.; Freitas, H.; Geraldes, C. F. G. C.; Castro, M. M. C. A.Li+ transport, intracellular immobilisation and Li+/Mg2+ competition were studied in Li+-loaded bovine chromaffin cells. Li+ influx rate constants, ki, obtained by atomic absorption (AA) spectrophotometry, in control (without and with ouabain) and depolarising (without and with nitrendipine) conditions, showed that L-type voltage-sensitive Ca2+ channels have an important role in Li+ uptake under depolarising co...
Intracellular lithium and cyclic AMP levels are mutually regulated in neuronal ...
Montezinho, L. P.; Duarte, C. B.; Fonseca, C. P.; Glinka, Y.; Layden, B.; Freitas, D. Mota de; Geraldes, C. F. G. C.; Castro, M. M. C. A.In this work, we studied the effect of intracellular 3',5'-cyclic adenosine monophosphate (cAMP) on Li+ transport in SH-SY5Y cells. The cells were stimulated with forskolin, an adenylate cyclase activator, or with the cAMP analogue, dibutyryl-cAMP. It was observed that under forskolin stimulation both the Li+ influx rate constant and the Li+ accumulation in these cells were increased. Dibutyryl-cAMP also increa...
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