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Increased breast cancer cell toxicity by palladination of the polyamine analogu...
Silva, Tânia M.; Fiuza, Sonia M.; Marques, Maria P. M.; Lo, Persson; Oredsson, StinaBreast cancer is one of the most common malignant tumor forms among women and many women succumb to their disease. Thus, new anticancer agents that can efficiently improve patient survival are of the utmost importance. In this study, the effects of the polyamine analogues N1,N11-bis(ethyl)norspermine (BENSpm) and N1-cyclo-propylmethyl-N11-ethylnorspermine (CPENSpm) and the synthesized dinuclear complexes Pd2BEN...
Use of Effective Core Potential Calculations for the Conformational and Vibrati...
Fiuza, Sónia M.; Amado, Ana M.; Marques, Maria P. M.; Carvalho, Luis A. E. Batista deIn the light of the recognized anticancer properties of cisplatin-type inorganic systems, the exact knowledge of their conformational preferences is of the utmost importance for understanding their biological activity. The present study reports the use of theoretical (quantum mechanical) calculations for achieving this goal. An alternative calculation method to the use of the AE basis sets, both accurate and co...
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