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Visualization of biochemical alterations. Oncological applications
Maria Filomena BotelhoNuclear Medicine is able of mapping and quantifying local activity, related with specific characteristics linked to some biochemical pathways involved in the malignant transformation or tumour proliferation.(...) ; Nuclear Medicine is able of mapping and quantifying local activity, related with specific characteristics linked to some biochemical pathways involved in the malignant transformation or tumour proli...
Cytogenetic Alterations Induced by Radiation in Amniocytes
Ana Salomé Pires; Marta Pinto; Paula Silveira; Ana Filipa Brito; Sérgio Fonseca; Ismael Castro; Sílvia Diaz; Ana Luísa Cunha; Marisa FerreiraWhen cells are submitted to ionizing radiation, they respond with physico-chemical phenomena like ionization/excitation of atoms and energy distribution over the cells, chemical reactions with formation of free radicals and rupture of chemical bonds and biological alterations leading to specific changes of cellular functions with decrease of cellular activity. Therefore, both tissues and organs are affecte...
Effect of ionizing radiation on rat peritoneal macrophages
Ana Cunha; António Lourenço; João Cancela; João Castelhano; Sara Carvalho; Ana Saiote; Áurea Matias; Emília Reis; Carmo Lopes; Ana SantosThis study aims to evaluate the survival rate of peritoneal rat macrophages after exposure to 3 & 6 Gy ionizing radiation fields, respectively. Cells were cultured in multiwell plates (37 ºC, 5% CO2), separated in 3 groups: GI–control; GII-cells irradiated with 3 Gy; GIII–cells irradiated with 6 Gy, using a 4 MeV particle accelerator. After irradiation cells were incubated for 2h30 = T0, 13...
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