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Impact of Biosimilars in Psoriasis Treatment

Churg-Strauss syndrome: a disabling disease.

Churg-Strauss syndrome (CSS) is an infrequent vasculitis that affects small to medium-sized vessels. We describe a 51 year-old-female admitted to our inpatient unit with bullae on her right foot and forearm with pain, paresthesias and impotence of the foot. There was rapid clinical deterioration with lost of gait and peripheral eosinophilia. Histopathology showed many extravascular eosinophils. Bone marrow had ...

Normas de Boa Prática para o Tratamento da Psoríase em Placas em Idade Não Pedi...

A psoríase é uma dermatose inflamatória, que afecta cerca de 2% da população mundial, com envolvimento preferencial cutâneo e articular, mas frequentemente associada a co-morbilidades importantes. Cerca de 20-30% dos doentes têm formas moderadas a graves, não controláveis por tratamentos tópicos. As terapêuticas sistémicas clássicas – PUVAterapia oral, retinóides, ciclosporina e metotrexato – podem induzir toxi...

A penalty method and a regularization strategy to solve MPCC

The goal of this paper is to solve mathematical programme with complementarity constraints using nonlinear programming techniques. This work presents two algorithms based on several nonlinear techniques such as sequential quadratic programming, penalty techniques and regularization schemes. A set of AMPL (A Modeling Language for Mathematical Programming) problems were tested and the computational experience sho...

Avaliação dos sítios dos hotéis de 4 e 5 estrelas da cidade de Lisboa

O uso da internet é cada vez mais comum. A inovação neste ramo da tecnologia é vertiginosa surgindo, dia após dia, novos componentes, com novas características. A internet teve o crescimento mais rápido da história e a sua taxa de penetração não se compara com a de qualquer outro meio de comunicação. Paralelamente a esta evolução ocorre a evolução dos mercados e o mercado turístico não é excepção, sendo o cresc...

Fluorescent products in the crystalline lens of type ii diabetic patients.

A body of evidence suggests that glycation of proteins and the resulting fluorescent products take part in the late complications of diabetes. The purpose of this study was to analyse the fluorescence of lens soluble proteins from diabetic patients. Soluble proteins were obtained from lens with cataract from 20 type II diabetic patients and from 21 non diabetic controls with similar age. The fluorescence of the...

Stress proteins.

Cells from all organisms have developed a remarkable number of strategies to deal with adverse changes in their environment. One of these protective mechanisms is the heat shock response, or stress response, characterized by the extremely rapid increased expression of a selected group of proteins--the heat shock proteins (hsp)--after a sudden increase in the normal cellular growth temperature. The same response...