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The role of Notch signaling in thymic epithelium development

Tese de mestrado. Biologia (Biologia Evolutiva e do Desenvolvimento). Universidade de Lisboa, Faculdade de Ciências, 2011 ; The thymus generates central immune tolerance by producing self-restricted and self-tolerant T-cells as a result of interactions between developing thymocytes and thymic epithelial cells (TECs). While the functional importance of TECs is well established, the mechanisms that direct their ...