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Oral Contraceptive Use and Clinical Outcomes in Patients with Multiple Sclerosis
Sena, A; Couderc, R; Vasconcelos, J; Ferret-Sena, V; Pedrosa, RExperimental and clinical data suggest a role of sex steroids in the pathogenesis of multiple sclerosis (MS). Scant information is available about the potential effect of oral contraceptive (OC) use on the prognosis of the disease. We aimed to evaluate this. The study population consisted of 132 women with relapsing-remitting MS before receiving disease modifying treatment and a mean disease duration 6.2 (SD 5....
Influence of Apolipoprotein E Plasma Levels and Tobacco Smoking on the Inductio...
Sena, A; Bendtzen, K; Cascais, MJ; Pedrosa, R; Ferret-Sena, V; Campos, EInterferon-beta (IFN-beta) therapy for multiple sclerosis (MS) is associated with a potential for induction of neutralizing antibodies (NAbs). Because immune reactivity depends on changes in lipoprotein metabolism, we investigated whether plasma lipoprotein profiles could be associated with the development of NAbs. Thirty-one female MS patients treated with subcutaneously administered IFN-beta were included. De...
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